Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients

M. Molnár, Edmund Huang, Junichi Hoshino, Mahesh Krishnan, Allen R. Nissenson, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECTIVE - Observational studies have yielded inconsistent findings regarding the association of hemoglobin A 1c (HbA 1c) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear. RESEARCH DESIGN AND METHOD - Linking the 5-year patient data of a large dialysis organization (DaVita) to the Scientific Registry of Transplant Recipients, we identified 2,872 diabetic dialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function (DGF) risks were estimated by Cox regression (hazard ratio [HR]) and logistic regression (odds ratio), respectively. RESULT - Patients were 53 ± 11 years old and included 36% women and 24% African Americans. In our fully adjusted model, allograft failure-censored, all-cause death HR and 95% CI for time-averaged pretransplant HbA 1c categories of 7 to 1c levels. CONCLUSION - Poor pretransplant glycemic control appears associated with decreased posttransplant survival in kidney transplant recipients, whereas allograft outcomes may not be affected.

Original languageEnglish
Pages (from-to)2536-2541
Number of pages6
JournalDiabetes Care
Volume34
Issue number12
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Hemoglobin A
Kidney
Dialysis
Allografts
Delayed Graft Function
Survival
African Americans
Kidney Transplantation
Observational Studies
Registries
Cause of Death
Research Design
Logistic Models
Odds Ratio
Organizations
Transplants
Mortality
Transplant Recipients

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Molnár, M., Huang, E., Hoshino, J., Krishnan, M., Nissenson, A. R., Kovesdy, C. P., & Kalantar-Zadeh, K. (2011). Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients. Diabetes Care, 34(12), 2536-2541. https://doi.org/10.2337/dc11-0906

Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients. / Molnár, M.; Huang, Edmund; Hoshino, Junichi; Krishnan, Mahesh; Nissenson, Allen R.; Kovesdy, Csaba P.; Kalantar-Zadeh, Kamyar.

In: Diabetes Care, Vol. 34, No. 12, 12.2011, p. 2536-2541.

Research output: Contribution to journalArticle

Molnár, M, Huang, E, Hoshino, J, Krishnan, M, Nissenson, AR, Kovesdy, CP & Kalantar-Zadeh, K 2011, 'Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients', Diabetes Care, vol. 34, no. 12, pp. 2536-2541. https://doi.org/10.2337/dc11-0906
Molnár, M. ; Huang, Edmund ; Hoshino, Junichi ; Krishnan, Mahesh ; Nissenson, Allen R. ; Kovesdy, Csaba P. ; Kalantar-Zadeh, Kamyar. / Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients. In: Diabetes Care. 2011 ; Vol. 34, No. 12. pp. 2536-2541.
@article{abaadc5926f54d519bab9aec23220a5e,
title = "Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients",
abstract = "OBJECTIVE - Observational studies have yielded inconsistent findings regarding the association of hemoglobin A 1c (HbA 1c) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear. RESEARCH DESIGN AND METHOD - Linking the 5-year patient data of a large dialysis organization (DaVita) to the Scientific Registry of Transplant Recipients, we identified 2,872 diabetic dialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function (DGF) risks were estimated by Cox regression (hazard ratio [HR]) and logistic regression (odds ratio), respectively. RESULT - Patients were 53 ± 11 years old and included 36{\%} women and 24{\%} African Americans. In our fully adjusted model, allograft failure-censored, all-cause death HR and 95{\%} CI for time-averaged pretransplant HbA 1c categories of 7 to 1c levels. CONCLUSION - Poor pretransplant glycemic control appears associated with decreased posttransplant survival in kidney transplant recipients, whereas allograft outcomes may not be affected.",
author = "M. Moln{\'a}r and Edmund Huang and Junichi Hoshino and Mahesh Krishnan and Nissenson, {Allen R.} and Kovesdy, {Csaba P.} and Kamyar Kalantar-Zadeh",
year = "2011",
month = "12",
doi = "10.2337/dc11-0906",
language = "English",
volume = "34",
pages = "2536--2541",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "12",

}

TY - JOUR

T1 - Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients

AU - Molnár, M.

AU - Huang, Edmund

AU - Hoshino, Junichi

AU - Krishnan, Mahesh

AU - Nissenson, Allen R.

AU - Kovesdy, Csaba P.

AU - Kalantar-Zadeh, Kamyar

PY - 2011/12

Y1 - 2011/12

N2 - OBJECTIVE - Observational studies have yielded inconsistent findings regarding the association of hemoglobin A 1c (HbA 1c) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear. RESEARCH DESIGN AND METHOD - Linking the 5-year patient data of a large dialysis organization (DaVita) to the Scientific Registry of Transplant Recipients, we identified 2,872 diabetic dialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function (DGF) risks were estimated by Cox regression (hazard ratio [HR]) and logistic regression (odds ratio), respectively. RESULT - Patients were 53 ± 11 years old and included 36% women and 24% African Americans. In our fully adjusted model, allograft failure-censored, all-cause death HR and 95% CI for time-averaged pretransplant HbA 1c categories of 7 to 1c levels. CONCLUSION - Poor pretransplant glycemic control appears associated with decreased posttransplant survival in kidney transplant recipients, whereas allograft outcomes may not be affected.

AB - OBJECTIVE - Observational studies have yielded inconsistent findings regarding the association of hemoglobin A 1c (HbA 1c) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear. RESEARCH DESIGN AND METHOD - Linking the 5-year patient data of a large dialysis organization (DaVita) to the Scientific Registry of Transplant Recipients, we identified 2,872 diabetic dialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function (DGF) risks were estimated by Cox regression (hazard ratio [HR]) and logistic regression (odds ratio), respectively. RESULT - Patients were 53 ± 11 years old and included 36% women and 24% African Americans. In our fully adjusted model, allograft failure-censored, all-cause death HR and 95% CI for time-averaged pretransplant HbA 1c categories of 7 to 1c levels. CONCLUSION - Poor pretransplant glycemic control appears associated with decreased posttransplant survival in kidney transplant recipients, whereas allograft outcomes may not be affected.

UR - http://www.scopus.com/inward/record.url?scp=84857791539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857791539&partnerID=8YFLogxK

U2 - 10.2337/dc11-0906

DO - 10.2337/dc11-0906

M3 - Article

VL - 34

SP - 2536

EP - 2541

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 12

ER -