Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients

Miklos Z. Molnar, Edmund Huang, Junichi Hoshino, Mahesh Krishnan, Allen R. Nissenson, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh

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Abstract

OBJECTIVE - Observational studies have yielded inconsistent findings regarding the association of hemoglobin A 1c (HbA 1c) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear. RESEARCH DESIGN AND METHOD - Linking the 5-year patient data of a large dialysis organization (DaVita) to the Scientific Registry of Transplant Recipients, we identified 2,872 diabetic dialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function (DGF) risks were estimated by Cox regression (hazard ratio [HR]) and logistic regression (odds ratio), respectively. RESULT - Patients were 53 ± 11 years old and included 36% women and 24% African Americans. In our fully adjusted model, allograft failure-censored, all-cause death HR and 95% CI for time-averaged pretransplant HbA 1c categories of 7 to <8%, 8 to <9%, 9 to 10%, and ≥10%, compared with 6 to <7% (reference), were 0.89 (0.59-1.36), 2.06 (1.31-3.24), 1.41 (0.73-2.74), and 3.43 (1.56-7.56), respectively; and graft failure-censored cardiovascular death HR was 0.38 (0.13-1.05), 1.78 (0.69-4.55), 1.59 (0.44-5.76), and 4.28 (0.85-21.64), respectively. We did not find any difference in risk of death-censored graft failure or DGF with different pretransplant HbA 1c levels. CONCLUSION - Poor pretransplant glycemic control appears associated with decreased posttransplant survival in kidney transplant recipients, whereas allograft outcomes may not be affected.

Original languageEnglish
Pages (from-to)2536-2541
Number of pages6
JournalDiabetes care
Volume34
Issue number12
DOIs
Publication statusPublished - Dec 1 2011

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Molnar, M. Z., Huang, E., Hoshino, J., Krishnan, M., Nissenson, A. R., Kovesdy, C. P., & Kalantar-Zadeh, K. (2011). Association of pretransplant glycemic controlwith posttransplant outcomes in diabetic kidney transplant recipients. Diabetes care, 34(12), 2536-2541. https://doi.org/10.2337/dc11-0906