Association of Porcine Circovirus Type 2 With Vascular Lesions in Porcine Pneumonia

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to evaluate the vasculature in porcine circovirus type 2-infected (PCV2-infected) lungs and to identify the PCV2 subtypes involved in porcine pneumonia. Pulmonary samples from 140 pigs, 2 weeks to 7 months of age, from 36 Hungarian commercial herds with clinical signs of respiratory disease were examined for the presence of respiratory pathogens, with bacterial culture, pathologic evaluation, and immunohistochemistry for PCV2, porcine reproductive respiratory syndrome virus, and swine influenza virus. PCV2 was the most commonly identified pathogen (49 cases) among the 74 of 140 cases (53%) with respiratory pathogens. PCV2 was detected immunohistochemically in the wall of 13% to 100% of pulmonary vessels (mean, 89%) in 38 of 49 cases (78%). Detection of PCV2 antigen was positively correlated with the presence of vascular lesions (P <.001, odds ratio [OR]: 159.54). Other pathogens capable of vascular injury in swine were found in 29 of 49 of the PCV2-positive cases (59%). The probability of detecting vascular lesions in PCV2-infected lung was higher than in infection with porcine reproductive respiratory syndrome virus (P <.002, OR: 14.63), Pasteurella multocida infection (P

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalVeterinary Pathology
Volume49
Issue number2
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Circovirus
Porcine circovirus-2
blood vessels
lesions (animal)
pneumonia
Blood Vessels
Pneumonia
Swine
lungs
Porcine respiratory and reproductive syndrome virus
Lung
swine
pathogens
odds ratio
Odds Ratio
Pasteurella Infections
Pasteurella multocida
antigen detection
Porcine reproductive and respiratory syndrome virus
Vascular System Injuries

Keywords

  • immunohistochemistry
  • porcine circovirus type 2
  • swine respiratory disease
  • vascular lesions

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Association of Porcine Circovirus Type 2 With Vascular Lesions in Porcine Pneumonia. / Szeredi, L.; Dán, A.; Solymosi, N.; Cságola, A.; Tuboly, T.

In: Veterinary Pathology, Vol. 49, No. 2, 03.2012, p. 264-270.

Research output: Contribution to journalArticle

@article{150d59cff90345088de6405982f6e807,
title = "Association of Porcine Circovirus Type 2 With Vascular Lesions in Porcine Pneumonia",
abstract = "The aim of this study was to evaluate the vasculature in porcine circovirus type 2-infected (PCV2-infected) lungs and to identify the PCV2 subtypes involved in porcine pneumonia. Pulmonary samples from 140 pigs, 2 weeks to 7 months of age, from 36 Hungarian commercial herds with clinical signs of respiratory disease were examined for the presence of respiratory pathogens, with bacterial culture, pathologic evaluation, and immunohistochemistry for PCV2, porcine reproductive respiratory syndrome virus, and swine influenza virus. PCV2 was the most commonly identified pathogen (49 cases) among the 74 of 140 cases (53{\%}) with respiratory pathogens. PCV2 was detected immunohistochemically in the wall of 13{\%} to 100{\%} of pulmonary vessels (mean, 89{\%}) in 38 of 49 cases (78{\%}). Detection of PCV2 antigen was positively correlated with the presence of vascular lesions (P <.001, odds ratio [OR]: 159.54). Other pathogens capable of vascular injury in swine were found in 29 of 49 of the PCV2-positive cases (59{\%}). The probability of detecting vascular lesions in PCV2-infected lung was higher than in infection with porcine reproductive respiratory syndrome virus (P <.002, OR: 14.63), Pasteurella multocida infection (P",
keywords = "immunohistochemistry, porcine circovirus type 2, swine respiratory disease, vascular lesions",
author = "L. Szeredi and A. D{\'a}n and N. Solymosi and A. Cs{\'a}gola and T. Tuboly",
year = "2012",
month = "3",
doi = "10.1177/0300985811406888",
language = "English",
volume = "49",
pages = "264--270",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Association of Porcine Circovirus Type 2 With Vascular Lesions in Porcine Pneumonia

AU - Szeredi, L.

AU - Dán, A.

AU - Solymosi, N.

AU - Cságola, A.

AU - Tuboly, T.

PY - 2012/3

Y1 - 2012/3

N2 - The aim of this study was to evaluate the vasculature in porcine circovirus type 2-infected (PCV2-infected) lungs and to identify the PCV2 subtypes involved in porcine pneumonia. Pulmonary samples from 140 pigs, 2 weeks to 7 months of age, from 36 Hungarian commercial herds with clinical signs of respiratory disease were examined for the presence of respiratory pathogens, with bacterial culture, pathologic evaluation, and immunohistochemistry for PCV2, porcine reproductive respiratory syndrome virus, and swine influenza virus. PCV2 was the most commonly identified pathogen (49 cases) among the 74 of 140 cases (53%) with respiratory pathogens. PCV2 was detected immunohistochemically in the wall of 13% to 100% of pulmonary vessels (mean, 89%) in 38 of 49 cases (78%). Detection of PCV2 antigen was positively correlated with the presence of vascular lesions (P <.001, odds ratio [OR]: 159.54). Other pathogens capable of vascular injury in swine were found in 29 of 49 of the PCV2-positive cases (59%). The probability of detecting vascular lesions in PCV2-infected lung was higher than in infection with porcine reproductive respiratory syndrome virus (P <.002, OR: 14.63), Pasteurella multocida infection (P

AB - The aim of this study was to evaluate the vasculature in porcine circovirus type 2-infected (PCV2-infected) lungs and to identify the PCV2 subtypes involved in porcine pneumonia. Pulmonary samples from 140 pigs, 2 weeks to 7 months of age, from 36 Hungarian commercial herds with clinical signs of respiratory disease were examined for the presence of respiratory pathogens, with bacterial culture, pathologic evaluation, and immunohistochemistry for PCV2, porcine reproductive respiratory syndrome virus, and swine influenza virus. PCV2 was the most commonly identified pathogen (49 cases) among the 74 of 140 cases (53%) with respiratory pathogens. PCV2 was detected immunohistochemically in the wall of 13% to 100% of pulmonary vessels (mean, 89%) in 38 of 49 cases (78%). Detection of PCV2 antigen was positively correlated with the presence of vascular lesions (P <.001, odds ratio [OR]: 159.54). Other pathogens capable of vascular injury in swine were found in 29 of 49 of the PCV2-positive cases (59%). The probability of detecting vascular lesions in PCV2-infected lung was higher than in infection with porcine reproductive respiratory syndrome virus (P <.002, OR: 14.63), Pasteurella multocida infection (P

KW - immunohistochemistry

KW - porcine circovirus type 2

KW - swine respiratory disease

KW - vascular lesions

UR - http://www.scopus.com/inward/record.url?scp=84857680857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857680857&partnerID=8YFLogxK

U2 - 10.1177/0300985811406888

DO - 10.1177/0300985811406888

M3 - Article

C2 - 21551427

AN - SCOPUS:84857680857

VL - 49

SP - 264

EP - 270

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 2

ER -