Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs

K. Hejjas, J. Vas, J. Topál, E. Szantai, Z. Rónai, A. Székely, E. Kubinyi, Z. Horvath, M. Sasvári, A. Miklósi

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

A variable number of tandem repeats (VNTR) polymorphism in exon 3 of the human dopamine D4 receptor gene (DRD4) has been associated with attention deficit hyperactivity disorder (ADHD). Rodents possess no analogous repeat sequence, whereas a similar tandem repeat polymorphism of the DRD4 gene was identified in dogs, horses and chimpanzees. Here, we present a genetic association study of the DRD4 VNTR and the activity-impulsivity dimension of the recently validated dog-ADHD Rating Scale. To avoid false positives arising from population stratification, a single breed of dogs (German shepherd) was studied. Two DRD4 alleles (referred to as 2 and 3a) were detected in this breed, and genotype frequencies were in Hardy-Weinberg equilibrium. For modelling distinct environmental conditions, 'pet' and 'police' German shepherds were characterized. Police German shepherds possessing at least one 3a allele showed significantly higher scores in the activity-impulsivity dimension of the dog-ADHD Rating Scale than dogs without this allele (P = 0.0180). This difference was not significant in pet German shepherds. To the best of our knowledge, this is the first report of an association between a candidate gene and a behaviour trait in dogs, and it reinforces the functional role of DRD4 exon 3 polymorphism.

Original languageEnglish
Pages (from-to)629-633
Number of pages5
JournalAnimal Genetics
Volume38
Issue number6
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Dopamine D4 Receptors
Endophenotypes
Impulsive Behavior
German Shepherd
genetic polymorphism
Dogs
dogs
Attention Deficit Disorder with Hyperactivity
police
rating scales
minisatellite repeats
Genes
Minisatellite Repeats
alleles
genes
Alleles
Pets
pets
exons
Police

Keywords

  • Activity-impulsivity
  • Dog
  • Dopamine D4 receptor gene
  • Genetic association
  • Polymorphism

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Genetics(clinical)

Cite this

Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs. / Hejjas, K.; Vas, J.; Topál, J.; Szantai, E.; Rónai, Z.; Székely, A.; Kubinyi, E.; Horvath, Z.; Sasvári, M.; Miklósi, A.

In: Animal Genetics, Vol. 38, No. 6, 12.2007, p. 629-633.

Research output: Contribution to journalArticle

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