Association of nonsyndromic Wilms tumor with premature centromere division (PCD)

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Abstract

Wilms tumor was discovered in a 22-month-old otherwise healthy girl. Her pretreatment karyotype proved to be normal 46,XX with total premature division (PCD) in 21% of her lymphocyte mitoses. This phenomenon was not seen in the parents. PCD was found in less than 4% of lymphocyte mitoses of five other children with Wilms tumor. The individual finding provides further evidence for a relation of PCD to tumorigenesis; however, elucidation of the question needs further systematic studies.

Original languageEnglish
Pages (from-to)215-216
Number of pages2
JournalAmerican journal of medical genetics
Volume112
Issue number2
DOIs
Publication statusPublished - Oct 1 2002

Keywords

  • Cancer susceptibility
  • Chromosome instability
  • PCD
  • Premature centromere division
  • Wilms tumor

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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