Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children

Szilvia Bokor, Katalin Csernus, Éva Erhardt, István Burus, Dénes Molnár, Tamás Decsi

Research output: Contribution to journalArticle

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Abstract

Aim: To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children. Methods: Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children. Results: Values of dihomo-γ-linolenic acid (C20:3n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], % weight/weight, median [interquartile range], p < 0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p < 0.05). Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations. Conclusions: Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.

Original languageEnglish
Pages (from-to)1350-1354
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume96
Issue number9
DOIs
Publication statusPublished - Sep 1 2007

Keywords

  • Arachidonic acid
  • Dihomo-gamma-linolenic acid
  • Insulin resistance
  • Uncoupling protein 2

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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