Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase

Blanka Kellermayer, Noemi Polgar, J. Pál, Miklos Banati, A. Maász, P. Kisfali, Zsolt Hosszu, Annamaria Juhasz, Henrik Boye Jensen, A. Tordai, C. Rózsa, B. Melegh, Zsolt Illes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine. Histamine modulates immune responses and plays a role in the pathogenesis of autoimmune disorders. Methods: The non-synonymous HNMT C314T polymorphism and the A939G single-nucleotide polymorphism (SNP) influencing HNMT mRNA stability were genotyped in 213 patients with myasthenia gravis (MG) and 342 healthy controls. Results: The carrier frequency of the A allele of the A939G SNP was over-represented among patients with anti-AchR and anti-Titin antibodies (P= 0.05 and P= 0.004, respectively); the presence of the minor G allele was protective against anti-AchR and anti-Titin positive MG (OR = 0.67 and OR = 0.54, respectively). The combination of the G allele carrier status with wild-type C314C homozygosity was also protective against MG (OR = 0.55, P= 0.008) and against the development of anti-AchR antibodies (OR = 0.37, P= 0.01). Discussion: The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found.

Original languageEnglish
Pages (from-to)1701-1704
Number of pages4
JournalHuman Immunology
Volume74
Issue number12
DOIs
Publication statusPublished - 2013

Fingerprint

Histamine N-Methyltransferase
Myasthenia Gravis
Connectin
Single Nucleotide Polymorphism
Histamine
Genes
Anti-Idiotypic Antibodies
Alleles
RNA Stability
Gene Frequency
Enzymes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase. / Kellermayer, Blanka; Polgar, Noemi; Pál, J.; Banati, Miklos; Maász, A.; Kisfali, P.; Hosszu, Zsolt; Juhasz, Annamaria; Jensen, Henrik Boye; Tordai, A.; Rózsa, C.; Melegh, B.; Illes, Zsolt.

In: Human Immunology, Vol. 74, No. 12, 2013, p. 1701-1704.

Research output: Contribution to journalArticle

Kellermayer, Blanka ; Polgar, Noemi ; Pál, J. ; Banati, Miklos ; Maász, A. ; Kisfali, P. ; Hosszu, Zsolt ; Juhasz, Annamaria ; Jensen, Henrik Boye ; Tordai, A. ; Rózsa, C. ; Melegh, B. ; Illes, Zsolt. / Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase. In: Human Immunology. 2013 ; Vol. 74, No. 12. pp. 1701-1704.
@article{a2140d4e112d4da9bf442f125905d580,
title = "Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase",
abstract = "Introduction: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine. Histamine modulates immune responses and plays a role in the pathogenesis of autoimmune disorders. Methods: The non-synonymous HNMT C314T polymorphism and the A939G single-nucleotide polymorphism (SNP) influencing HNMT mRNA stability were genotyped in 213 patients with myasthenia gravis (MG) and 342 healthy controls. Results: The carrier frequency of the A allele of the A939G SNP was over-represented among patients with anti-AchR and anti-Titin antibodies (P= 0.05 and P= 0.004, respectively); the presence of the minor G allele was protective against anti-AchR and anti-Titin positive MG (OR = 0.67 and OR = 0.54, respectively). The combination of the G allele carrier status with wild-type C314C homozygosity was also protective against MG (OR = 0.55, P= 0.008) and against the development of anti-AchR antibodies (OR = 0.37, P= 0.01). Discussion: The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found.",
author = "Blanka Kellermayer and Noemi Polgar and J. P{\'a}l and Miklos Banati and A. Ma{\'a}sz and P. Kisfali and Zsolt Hosszu and Annamaria Juhasz and Jensen, {Henrik Boye} and A. Tordai and C. R{\'o}zsa and B. Melegh and Zsolt Illes",
year = "2013",
doi = "10.1016/j.humimm.2013.07.016",
language = "English",
volume = "74",
pages = "1701--1704",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase

AU - Kellermayer, Blanka

AU - Polgar, Noemi

AU - Pál, J.

AU - Banati, Miklos

AU - Maász, A.

AU - Kisfali, P.

AU - Hosszu, Zsolt

AU - Juhasz, Annamaria

AU - Jensen, Henrik Boye

AU - Tordai, A.

AU - Rózsa, C.

AU - Melegh, B.

AU - Illes, Zsolt

PY - 2013

Y1 - 2013

N2 - Introduction: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine. Histamine modulates immune responses and plays a role in the pathogenesis of autoimmune disorders. Methods: The non-synonymous HNMT C314T polymorphism and the A939G single-nucleotide polymorphism (SNP) influencing HNMT mRNA stability were genotyped in 213 patients with myasthenia gravis (MG) and 342 healthy controls. Results: The carrier frequency of the A allele of the A939G SNP was over-represented among patients with anti-AchR and anti-Titin antibodies (P= 0.05 and P= 0.004, respectively); the presence of the minor G allele was protective against anti-AchR and anti-Titin positive MG (OR = 0.67 and OR = 0.54, respectively). The combination of the G allele carrier status with wild-type C314C homozygosity was also protective against MG (OR = 0.55, P= 0.008) and against the development of anti-AchR antibodies (OR = 0.37, P= 0.01). Discussion: The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found.

AB - Introduction: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine. Histamine modulates immune responses and plays a role in the pathogenesis of autoimmune disorders. Methods: The non-synonymous HNMT C314T polymorphism and the A939G single-nucleotide polymorphism (SNP) influencing HNMT mRNA stability were genotyped in 213 patients with myasthenia gravis (MG) and 342 healthy controls. Results: The carrier frequency of the A allele of the A939G SNP was over-represented among patients with anti-AchR and anti-Titin antibodies (P= 0.05 and P= 0.004, respectively); the presence of the minor G allele was protective against anti-AchR and anti-Titin positive MG (OR = 0.67 and OR = 0.54, respectively). The combination of the G allele carrier status with wild-type C314C homozygosity was also protective against MG (OR = 0.55, P= 0.008) and against the development of anti-AchR antibodies (OR = 0.37, P= 0.01). Discussion: The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found.

UR - http://www.scopus.com/inward/record.url?scp=84888197370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888197370&partnerID=8YFLogxK

U2 - 10.1016/j.humimm.2013.07.016

DO - 10.1016/j.humimm.2013.07.016

M3 - Article

C2 - 23932992

AN - SCOPUS:84888197370

VL - 74

SP - 1701

EP - 1704

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 12

ER -