Association of microalbuminuria with slow acetylator phenotype in type 1 diabetes mellitus

L. Madácsy, I. Szorady, A. Santa, L. Barkai, I. Vamosi

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Abstract

The genetically determined acetylator phenotype in diabetic children with and without increased urinary albumin excretion was investigated. Acetylator phenotype was determined according to Evans, and 24-hour albumin excretion rate (AER) was measured by immunoturbidometry in 86 children and adolescents with type 1 (insulin-dependent) diabetes mellitus and in 100 age-matched healthy controls. In diabetics, the fast acetylator phenotype was found in 36 (41.9%) patients and the slow one in 50 (58.1%); the control group had 52 (52%) fast and 48 (48%) slow acetylators. There were no significant differences in acetylator phenotypes between diabetic patients and control subjects (χ2 = 1.0, NS). Among patients with normal albumin excretion (n = 70, mean age: 12.9 ± 3.5 years, mean diabetes duration: 5.3 ± 3.8 years, AER <20 μg/min), 35 (50%) fast acetylators and 35 (50%) slow acetylators were found. In patients with elevated albumin excretion (n = 16, mean age: 14.0 ± 3.2 years, mean diabetes duration: 4.9 ± 3.0 years, AER > 20 μg/min), 1 (6.3%) patient was a fast acetylator and 15 (93.7%) were slow acetylators. A significant difference has been found between the two groups in the rate of fast/slow acetylators (χ2 = 8.79, p <0.01). The strong correlation between the slow acetylator phenotype and microalbuminuria in diabetics suggests that: (a) genetic factors may play a role in the development of diabetic nephropathy; (b) the acetylator status could be a useful tool to detect patients 'at risk' of nephropathy.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalChild Nephrology and Urology
Volume12
Issue number4
Publication statusPublished - 1992

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Type 1 Diabetes Mellitus
Albumins
Phenotype
Diabetic Nephropathies
Control Groups

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Association of microalbuminuria with slow acetylator phenotype in type 1 diabetes mellitus. / Madácsy, L.; Szorady, I.; Santa, A.; Barkai, L.; Vamosi, I.

In: Child Nephrology and Urology, Vol. 12, No. 4, 1992, p. 192-196.

Research output: Contribution to journalArticle

Madácsy, L, Szorady, I, Santa, A, Barkai, L & Vamosi, I 1992, 'Association of microalbuminuria with slow acetylator phenotype in type 1 diabetes mellitus', Child Nephrology and Urology, vol. 12, no. 4, pp. 192-196.
Madácsy, L. ; Szorady, I. ; Santa, A. ; Barkai, L. ; Vamosi, I. / Association of microalbuminuria with slow acetylator phenotype in type 1 diabetes mellitus. In: Child Nephrology and Urology. 1992 ; Vol. 12, No. 4. pp. 192-196.
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