Association of maternal diseases during pregnancy with the risk of single ventricular septal defects in the offspring - A population-based case-control study

Melinda Csáky-Szunyogh, Attila Vereczkey, Zsolt Kósa, Róbert Urbán, Andrew E. Czeizel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: In general, the analytical epidemiological studies evaluated cases with congenital heart defects (CHDs) together. However, different CHD entities have different etiology, and in the vast majority of patients the underlying causes are unclear. Thus the objective of the study was to evaluate the possible etiological factors in the origin of single ventricular septal defect (VSD) after surgical intervention or lethal outcome, i.e. as homogeneous as possible. Method: In the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities acute and chronic maternal diseases with related drug treatments and pregnancy supplements in early pregnancy were evaluated in the mothers of 1661 cases with isolated/single VSD and their 2534 matched and 38151 all controls without defect, and 19833 malformed controls with other isolated non-cardiac defect. Results: There was a higher risk of VSD in the children of mothers with high fever related influenza during the critical period of VSD and this risk was limited by antifever therapy. In addition paroxysmal supraventricular tachycardia and epilepsy treated with anticonvulsant drugs associated with higher risk of VSD. Finally, the high doses of folic acid alone in early pregnancy. Conclusions: High-fever-related maternal diseases may have a role in the origin of VSD which is preventable with antifever drug therapy, and the high doses of folic acid in early pregnancy reduced the risk of VSD.

Original languageEnglish
Pages (from-to)738-747
Number of pages10
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume26
Issue number8
DOIs
Publication statusPublished - May 1 2013

Keywords

  • Antifever therapy
  • Epilepsy
  • Folic acid supplementation
  • Influenza
  • Paroxysmal supraventricular tachycardia
  • Population-based case-control study
  • Ventricular septal defect

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Association of maternal diseases during pregnancy with the risk of single ventricular septal defects in the offspring - A population-based case-control study'. Together they form a unique fingerprint.

  • Cite this