Association of lean and fat body mass, bone biomarkers and gonadal steroids with bone mass during pre-and midpuberty

Violetta Csakvary, E. Erhardt, P. Vargha, Gyorgy Oroszlan, Tamas Bodecs, Dora Torok, Erzsebet Toldy, G. Kovács

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background/Aims: The association of bone mass with body composition, bone turnover markers and gonadal steroids was examined in Hungarian children during pre-and midpuberty. Methods: Two hundred and thirty-seven 7-to 16-year-old subjects (56% girls) were investigated. Bone mineral density (BMD), fat mass and total and appendicular lean mass were estimated with dual-energy X-ray absorptiometry (Lunar Prodigy). The fat mass index and appendicular lean mass index (LMI) were calculated. Serum bone markers, parathyroid hormone, estradiol and testosterone were analyzed. Associations between variables were evaluated by multiple regression analysis. Results: During prepuberty, bone biomarkers, gonadal steroids and appendicular LMI were associated with bone mass in both genders (p <0.05). During midpuberty, girls' bone turnover markers were negatively associated with bone mass (p <0.001). In prepuberty, appendicular LMI and β-crosslaps were predictors of bone mass in both genders. During midpuberty, appendicular LMI and gonadal steroids positively contributed to bone mass in both genders, while osteocalcin exerted a negative influence on total and L1-L4 spine BMD in girls and on L1-L4 BMD in boys (all p <0.001). Conclusions: Predictors for bone development varied according to Tanner stage and gender. The most significant determinants of bone mass were appendicular LMI and estradiol.

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalHormone Research in Paediatrics
Volume78
Issue number4
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Fat Body
Biomarkers
Steroids
Bone and Bones
Bone Density
glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine
Bone Remodeling
Estradiol
Fats
Bone Development
Osteocalcin
Photon Absorptiometry
Body Composition
Parathyroid Hormone
Testosterone
Spine
Regression Analysis

Keywords

  • Body composition
  • Bone development
  • Bone markers
  • Puberty
  • Steroid hormones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Association of lean and fat body mass, bone biomarkers and gonadal steroids with bone mass during pre-and midpuberty. / Csakvary, Violetta; Erhardt, E.; Vargha, P.; Oroszlan, Gyorgy; Bodecs, Tamas; Torok, Dora; Toldy, Erzsebet; Kovács, G.

In: Hormone Research in Paediatrics, Vol. 78, No. 4, 11.2012, p. 203-211.

Research output: Contribution to journalArticle

Csakvary, Violetta ; Erhardt, E. ; Vargha, P. ; Oroszlan, Gyorgy ; Bodecs, Tamas ; Torok, Dora ; Toldy, Erzsebet ; Kovács, G. / Association of lean and fat body mass, bone biomarkers and gonadal steroids with bone mass during pre-and midpuberty. In: Hormone Research in Paediatrics. 2012 ; Vol. 78, No. 4. pp. 203-211.
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