Association of human fetuin-A rs4917 polymorphism with obesity in 2 cohorts

György Temesszentandrási, Krisztián Vörös, Zoltán Böröcz, Edit Kaszás, Z. Prohászka, A. Falus, K. Cseh, L. Kalabay

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Previous studies have shown association of the multifunctional hepatic protein α2HS-glycoprotein/human fetuin A with insulin resistance, type 2 diabetes mellitus, metabolic syndrome, obesity, and atherosclerosis. Reports of contribution of α2HS-glycoprotein/human fetuin A rs4917 single-nucleotide polymorphism to the development of these pathologic processes are inconsistent. We aimed to investigate the association between variants of rs4917 and parameters of obesity, lipid status, the proinflammatory cytokine tumor necrosis factor α (TNF-α), adipokines (adiponectin, resistin), and insulin resistance in 2 cohorts. Methods: Eighty-one healthy persons (cohort 1) and 157 patients with previous myocardial infarction (cohort 2) were included in this crosssectional study. rs4917 Polymorphism was determined by the allelespecific KASP by design genotyping assays. Results: In cohort 1, T-nucleotide carriers had lower low-density lipoprotein cholesterol levels compared with non-T carriers. The serum concentration of TNF-α was found to be higher carrying the non-T allele in cohort 1; however, this difference was not observed in cohort 2. In cohort 2, T carriers had lower body mass index and abdominal and waist circumferences than did non-T carriers. The T nucleotide was more frequent in nonobese than in obese patients (χ2 = 5.217, P = 0.022). Nonobese, nondiabetic T carriers still had lower body mass index and waist circumference than did non-T carriers. Conclusions: Our data suggest that the T nucleotide in rs4917 is associated with more favorable lipid status among healthy persons (i.e., lower low-density lipoprotein cholesterol) and anthropologic parameters of obesity in cohort 2. The protective role of the T allele may also be associated with lower TNF-α levels found in healthy individuals.

Original languageEnglish
Pages (from-to)548-553
Number of pages6
JournalJournal of Investigative Medicine
Volume63
Issue number3
DOIs
Publication statusPublished - Mar 11 2015

Fingerprint

Polymorphism
Nucleotides
Tumor Necrosis Factor-alpha
Obesity
Waist Circumference
LDL Cholesterol
Insulin Resistance
Glycoproteins
Body Mass Index
Alleles
Resistin
Lipids
Adipokines
Adiponectin
Association reactions
Pathologic Processes
Insulin
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Atherosclerosis

Keywords

  • diabetes mellitus
  • myocardial infarction
  • obesity
  • rs4917
  • α2HS-glycoprotein/fetuin A

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Association of human fetuin-A rs4917 polymorphism with obesity in 2 cohorts. / Temesszentandrási, György; Vörös, Krisztián; Böröcz, Zoltán; Kaszás, Edit; Prohászka, Z.; Falus, A.; Cseh, K.; Kalabay, L.

In: Journal of Investigative Medicine, Vol. 63, No. 3, 11.03.2015, p. 548-553.

Research output: Contribution to journalArticle

Temesszentandrási, György ; Vörös, Krisztián ; Böröcz, Zoltán ; Kaszás, Edit ; Prohászka, Z. ; Falus, A. ; Cseh, K. ; Kalabay, L. / Association of human fetuin-A rs4917 polymorphism with obesity in 2 cohorts. In: Journal of Investigative Medicine. 2015 ; Vol. 63, No. 3. pp. 548-553.
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AU - Böröcz, Zoltán

AU - Kaszás, Edit

AU - Prohászka, Z.

AU - Falus, A.

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AU - Kalabay, L.

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