Association of HELLP syndrome with primary antiphospholipid syndrome - A case report

K. Veres, Károly Papp, Gabriella Lakos, Edit Szomják, Z. Szekanecz, G. Szegedi, P. Soltész

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Authors present the first Hungarian case of a young pregnant woman with the association of antiphospholipid syndrome (APS) and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. After the onset of severe preeclampsia, the pregnancy was terminated but the patient's condition continued to worsen. New symptoms of APS, including deep vein thrombosis and ischemic nervus opticus lesion, developed in the patient followed by the onset of acute respiratory distress syndrome, which required respiratory therapy. Intensive treatment with plasmapheresis, high-dose intravenous immunoglobulin, high-dose corticosteroids, cyclophosphamide, and anticoagulants eventually led to full recovery. There have been only few scattered reports in the literature on the association of HELLP syndrome and APS, which was successfully managed with the combination of various immunosuppressive and immunomodulatory treatment modalities.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalClinical Rheumatology
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Antiphospholipid Syndrome
Hemolysis
Platelet Count
Liver
Enzymes
Respiratory Therapy
Plasmapheresis
Intravenous Immunoglobulins
Adult Respiratory Distress Syndrome
Immunosuppressive Agents
Optic Nerve
Pre-Eclampsia
Venous Thrombosis
Cyclophosphamide
Anticoagulants
Pregnant Women
Adrenal Cortex Hormones
Pregnancy
Therapeutics

Keywords

  • Antiphospholipid syndrome
  • Catastrophic antiphospholipid syndrome
  • Cyclophosphamide
  • HELLP syndrome
  • High-dose intravenous immunoglobulin therapy
  • Plasmapheresis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Association of HELLP syndrome with primary antiphospholipid syndrome - A case report. / Veres, K.; Papp, Károly; Lakos, Gabriella; Szomják, Edit; Szekanecz, Z.; Szegedi, G.; Soltész, P.

In: Clinical Rheumatology, Vol. 27, No. 1, 01.2008, p. 111-113.

Research output: Contribution to journalArticle

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