Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure

Z. Prohászka, Lea Munthe-Fog, Thor Ueland, Timea Gombos, Arne Yndestad, Zsolt Förhécz, Mikkel Ole Skjoedt, Zoltan Pozsonyi, Alice Gustavsen, Lívia Jánoskuti, I. Karádi, Lars Gullestad, Christen P. Dahl, Erik T. Askevold, G. Füst, Pål Aukrust, Tom E. Mollnes, Peter Garred

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background:Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure.Methods and Results:MBL, ficolin-2 and ficolin-3 plasma concentrations were determined in two consecutive cohorts comprising 190 patients from Hungary and 183 patients from Norway as well as controls. Disease severity and clinical parameters were determined at baseline, and all-cause mortality was registered after 5-years follow-up. In univariate analysis a low level of ficolin-3, but not that of MBL or ficolin-2, was significantly associated with advanced heart failure (New York Heart Association Class IV, p

Original languageEnglish
Article numbere60976
JournalPLoS One
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 15 2013

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heart failure
lectins
Heart Failure
mannose
Mannose-Binding Lectin
disease severity
complement
Mannose-Binding Lectin Complement Pathway
pathophysiology
Hungary
Norway
Complement Activation
heart
Lectins
ficolin
Chemical activation
Plasmas
Molecules
Mortality
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Prohászka, Z., Munthe-Fog, L., Ueland, T., Gombos, T., Yndestad, A., Förhécz, Z., ... Garred, P. (2013). Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure. PLoS One, 8(4), [e60976]. https://doi.org/10.1371/journal.pone.0060976

Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure. / Prohászka, Z.; Munthe-Fog, Lea; Ueland, Thor; Gombos, Timea; Yndestad, Arne; Förhécz, Zsolt; Skjoedt, Mikkel Ole; Pozsonyi, Zoltan; Gustavsen, Alice; Jánoskuti, Lívia; Karádi, I.; Gullestad, Lars; Dahl, Christen P.; Askevold, Erik T.; Füst, G.; Aukrust, Pål; Mollnes, Tom E.; Garred, Peter.

In: PLoS One, Vol. 8, No. 4, e60976, 15.04.2013.

Research output: Contribution to journalArticle

Prohászka, Z, Munthe-Fog, L, Ueland, T, Gombos, T, Yndestad, A, Förhécz, Z, Skjoedt, MO, Pozsonyi, Z, Gustavsen, A, Jánoskuti, L, Karádi, I, Gullestad, L, Dahl, CP, Askevold, ET, Füst, G, Aukrust, P, Mollnes, TE & Garred, P 2013, 'Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure', PLoS One, vol. 8, no. 4, e60976. https://doi.org/10.1371/journal.pone.0060976
Prohászka Z, Munthe-Fog L, Ueland T, Gombos T, Yndestad A, Förhécz Z et al. Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure. PLoS One. 2013 Apr 15;8(4). e60976. https://doi.org/10.1371/journal.pone.0060976
Prohászka, Z. ; Munthe-Fog, Lea ; Ueland, Thor ; Gombos, Timea ; Yndestad, Arne ; Förhécz, Zsolt ; Skjoedt, Mikkel Ole ; Pozsonyi, Zoltan ; Gustavsen, Alice ; Jánoskuti, Lívia ; Karádi, I. ; Gullestad, Lars ; Dahl, Christen P. ; Askevold, Erik T. ; Füst, G. ; Aukrust, Pål ; Mollnes, Tom E. ; Garred, Peter. / Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure. In: PLoS One. 2013 ; Vol. 8, No. 4.
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