Association of FcRn Heavy Chain encoding gene (FCGRT) POLYMORPHISMS with IgG content in bovine colostrum

Ran Zhang, Zhihui Zhao, Yaofeng Zhao, I. Kacskovics, Marjolein Van Der Eijk, Nanda De Groot, Ning Li, Lennart Hammarstrom

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level ([OR]=9.90, 95%CI=1.11-88.34, p=0.016) and haplotype 2 exhibited a similar trend ([OR]=2.89, 95%CI=1.17-7.11, p=0.019).

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalAnimal Biotechnology
Volume20
Issue number4
DOIs
Publication statusPublished - Oct 2009

Fingerprint

cow colostrum
Colostrum
Gene encoding
Nucleotides
Polymorphism
Haplotypes
haplotypes
Immunoglobulin G
Genes
genes
single nucleotide polymorphism
Single Nucleotide Polymorphism
Holstein
cows
cattle

Keywords

  • Bovine colostrum
  • FCGRT
  • IgG concentration
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biotechnology
  • Bioengineering

Cite this

Association of FcRn Heavy Chain encoding gene (FCGRT) POLYMORPHISMS with IgG content in bovine colostrum. / Zhang, Ran; Zhao, Zhihui; Zhao, Yaofeng; Kacskovics, I.; Eijk, Marjolein Van Der; Groot, Nanda De; Li, Ning; Hammarstrom, Lennart.

In: Animal Biotechnology, Vol. 20, No. 4, 10.2009, p. 242-246.

Research output: Contribution to journalArticle

Zhang, Ran ; Zhao, Zhihui ; Zhao, Yaofeng ; Kacskovics, I. ; Eijk, Marjolein Van Der ; Groot, Nanda De ; Li, Ning ; Hammarstrom, Lennart. / Association of FcRn Heavy Chain encoding gene (FCGRT) POLYMORPHISMS with IgG content in bovine colostrum. In: Animal Biotechnology. 2009 ; Vol. 20, No. 4. pp. 242-246.
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