Association of FcRn Heavy Chain encoding gene (FCGRT) POLYMORPHISMS with IgG content in bovine colostrum

Ran Zhang, Zhihui Zhao, Yaofeng Zhao, Imre Kacskovics, Marjolein Van Der Eijk, Nanda De Groot, Ning Li, Lennart Hammarstrom

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level ([OR]=9.90, 95%CI=1.11-88.34, p=0.016) and haplotype 2 exhibited a similar trend ([OR]=2.89, 95%CI=1.17-7.11, p=0.019).

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalAnimal Biotechnology
Volume20
Issue number4
DOIs
Publication statusPublished - Oct 1 2009

Keywords

  • Bovine colostrum
  • FCGRT
  • IgG concentration
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Animal Science and Zoology

Fingerprint Dive into the research topics of 'Association of FcRn Heavy Chain encoding gene (FCGRT) POLYMORPHISMS with IgG content in bovine colostrum'. Together they form a unique fingerprint.

  • Cite this