Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype

Results of a 25-year follow-up study

L. Lakatos, T. Pandúr, Gyula David, Zsuzsanna Balogh, Pal Kuronya, Arpad Tollas, P. Lakatos

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Aim: IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study. Methods: Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: 317/302, mean age at presentation: 38.3 years, average disease duration: 11.2 years; Crohn's disease/CD/: 254, m/f: 125/129, mean age at presentation: 32.5 years, average disease duration: 9.2 years). Intestinal, extraintestinal signs and laboratory tests were monitored regularly. Any alteration suggesting an EIMs was investigated by a specialist. Results: A total of 21.3 % of patients with IBD had EIM (UC: 15.0 %, CD: 36.6 %). Age at presentation did not affect the likelihood of EIM. Prevalence of EIMs was higher in women and in CD, ocular complications and primary sclerosing cholangitis (PSC) were more frequent in UC. In UC there was an increased tendency of EIM in patients with a more extensive disease. Joint complications were more frequent in CD (22.4 % vs UC 10.2 %, P

Original languageEnglish
Pages (from-to)2300-2307
Number of pages8
JournalWorld Journal of Gastroenterology
Volume9
Issue number10
Publication statusPublished - Oct 2003

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Hungary
Inflammatory Bowel Diseases
Phenotype
Sclerosing Cholangitis
Ulcerative Colitis
Crohn Disease
Joints

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype : Results of a 25-year follow-up study. / Lakatos, L.; Pandúr, T.; David, Gyula; Balogh, Zsuzsanna; Kuronya, Pal; Tollas, Arpad; Lakatos, P.

In: World Journal of Gastroenterology, Vol. 9, No. 10, 10.2003, p. 2300-2307.

Research output: Contribution to journalArticle

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abstract = "Aim: IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study. Methods: Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: 317/302, mean age at presentation: 38.3 years, average disease duration: 11.2 years; Crohn's disease/CD/: 254, m/f: 125/129, mean age at presentation: 32.5 years, average disease duration: 9.2 years). Intestinal, extraintestinal signs and laboratory tests were monitored regularly. Any alteration suggesting an EIMs was investigated by a specialist. Results: A total of 21.3 {\%} of patients with IBD had EIM (UC: 15.0 {\%}, CD: 36.6 {\%}). Age at presentation did not affect the likelihood of EIM. Prevalence of EIMs was higher in women and in CD, ocular complications and primary sclerosing cholangitis (PSC) were more frequent in UC. In UC there was an increased tendency of EIM in patients with a more extensive disease. Joint complications were more frequent in CD (22.4 {\%} vs UC 10.2 {\%}, P",
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