Association of desaturase activity and C-reactive protein in European children

Maike Wolters, Claudia Bornhorst, Heike Schwarz, Patrizia Rise, Claudio Galli, Luis A. Moreno, Valeria Pala, Paola Russo, Toomas Veidebaum, Michael Tornaritis, Arno Fraterman, Stefaan De Henauw, Gabriele Eiben, Lauren Lissner, D. Molnár, Wolfgang Ahrens

Research output: Contribution to journalArticle

Abstract

Background: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high-sensitive C-reactive protein (CRP) in young children. Methods: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (T0) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from T0 product-precursor FA ratios. CRP was measured at T0 and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. Results: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP ≥ Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. Conclusion: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalPediatric Research
Volume81
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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C-Reactive Protein
Fatty Acids
Dietary Carbohydrates
Inflammation
Monounsaturated Fatty Acids
Body Composition
Unsaturated Fatty Acids
Life Style
Blood Proteins
Cohort Studies
Weights and Measures
Health
Enzymes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Wolters, M., Bornhorst, C., Schwarz, H., Rise, P., Galli, C., Moreno, L. A., ... Ahrens, W. (2017). Association of desaturase activity and C-reactive protein in European children. Pediatric Research, 81(1), 27-32. https://doi.org/10.1038/pr.2016.186

Association of desaturase activity and C-reactive protein in European children. / Wolters, Maike; Bornhorst, Claudia; Schwarz, Heike; Rise, Patrizia; Galli, Claudio; Moreno, Luis A.; Pala, Valeria; Russo, Paola; Veidebaum, Toomas; Tornaritis, Michael; Fraterman, Arno; De Henauw, Stefaan; Eiben, Gabriele; Lissner, Lauren; Molnár, D.; Ahrens, Wolfgang.

In: Pediatric Research, Vol. 81, No. 1, 01.01.2017, p. 27-32.

Research output: Contribution to journalArticle

Wolters, M, Bornhorst, C, Schwarz, H, Rise, P, Galli, C, Moreno, LA, Pala, V, Russo, P, Veidebaum, T, Tornaritis, M, Fraterman, A, De Henauw, S, Eiben, G, Lissner, L, Molnár, D & Ahrens, W 2017, 'Association of desaturase activity and C-reactive protein in European children', Pediatric Research, vol. 81, no. 1, pp. 27-32. https://doi.org/10.1038/pr.2016.186
Wolters M, Bornhorst C, Schwarz H, Rise P, Galli C, Moreno LA et al. Association of desaturase activity and C-reactive protein in European children. Pediatric Research. 2017 Jan 1;81(1):27-32. https://doi.org/10.1038/pr.2016.186
Wolters, Maike ; Bornhorst, Claudia ; Schwarz, Heike ; Rise, Patrizia ; Galli, Claudio ; Moreno, Luis A. ; Pala, Valeria ; Russo, Paola ; Veidebaum, Toomas ; Tornaritis, Michael ; Fraterman, Arno ; De Henauw, Stefaan ; Eiben, Gabriele ; Lissner, Lauren ; Molnár, D. ; Ahrens, Wolfgang. / Association of desaturase activity and C-reactive protein in European children. In: Pediatric Research. 2017 ; Vol. 81, No. 1. pp. 27-32.
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abstract = "Background: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high-sensitive C-reactive protein (CRP) in young children. Methods: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (T0) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from T0 product-precursor FA ratios. CRP was measured at T0 and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. Results: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11{\%} higher risk of having a serum CRP ≥ Percentile 75 (P75) (OR, 99{\%} CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. Conclusion: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.",
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T1 - Association of desaturase activity and C-reactive protein in European children

AU - Wolters, Maike

AU - Bornhorst, Claudia

AU - Schwarz, Heike

AU - Rise, Patrizia

AU - Galli, Claudio

AU - Moreno, Luis A.

AU - Pala, Valeria

AU - Russo, Paola

AU - Veidebaum, Toomas

AU - Tornaritis, Michael

AU - Fraterman, Arno

AU - De Henauw, Stefaan

AU - Eiben, Gabriele

AU - Lissner, Lauren

AU - Molnár, D.

AU - Ahrens, Wolfgang

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high-sensitive C-reactive protein (CRP) in young children. Methods: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (T0) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from T0 product-precursor FA ratios. CRP was measured at T0 and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. Results: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP ≥ Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. Conclusion: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.

AB - Background: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high-sensitive C-reactive protein (CRP) in young children. Methods: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (T0) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from T0 product-precursor FA ratios. CRP was measured at T0 and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. Results: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP ≥ Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. Conclusion: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.

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