A veleszületett kromoszóma-rendellenességek és a malignus megbetegedések társulása.

Translated title of the contribution: Association of congenital chromosome abnormalities and malignant diseases

B. Erzsébet, N. Andrea, S. Róbert, O. Eva

Research output: Contribution to journalReview article

1 Citation (Scopus)


Chromosome studies were carried out on 112 children with acute leukemia and 10 children with solid tumor. Acquired chromosome abnormalities were identified shown in 52% of patients with hematologic disorders (ALL 40%, ANLL 64%) and in four of 10 patients with non-hematologic disorders. Six patients had a constitutional chromosome aberration: three of them with ANLL and one child with ALL had trisomy 21, an other one with ALL had balanced translocation [t(2;7)] of maternal origin, and one child with Wilms' tumor-anirida syndrome had del(11)(p13). Two Down syndrome children with ANLL had additional acquired karyotypic changes. One of the Down's syndrome patients with ANLL M2 had t(8;21), the karyotype of the leukemic cells was: 47, XY, t(8;21) +21c. The other case with 21;21 centric fusion had hyperdiploidy, extra chromosomes were: +8, +14, +19, +20. It is very important to distinguish acquired and constitutional abnormalities in tumor cells.

Translated title of the contributionAssociation of congenital chromosome abnormalities and malignant diseases
Original languageHungarian
Pages (from-to)227-231
Number of pages5
JournalOrvosi hetilap
Issue number5
Publication statusPublished - Feb 4 1996

ASJC Scopus subject areas

  • Medicine(all)

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