A veleszületett kromoszóma-rendellenességek és a malignus megbetegedések társulása.

Translated title of the contribution: Association of congenital chromosome abnormalities and malignant diseases

B. Erzsébet, N. Andrea, S. Róbert, E. Oláh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chromosome studies were carried out on 112 children with acute leukemia and 10 children with solid tumor. Acquired chromosome abnormalities were identified shown in 52% of patients with hematologic disorders (ALL 40%, ANLL 64%) and in four of 10 patients with non-hematologic disorders. Six patients had a constitutional chromosome aberration: three of them with ANLL and one child with ALL had trisomy 21, an other one with ALL had balanced translocation [t(2;7)] of maternal origin, and one child with Wilms' tumor-anirida syndrome had del(11)(p13). Two Down syndrome children with ANLL had additional acquired karyotypic changes. One of the Down's syndrome patients with ANLL M2 had t(8;21), the karyotype of the leukemic cells was: 47, XY, t(8;21) +21c. The other case with 21;21 centric fusion had hyperdiploidy, extra chromosomes were: +8, +14, +19, +20. It is very important to distinguish acquired and constitutional abnormalities in tumor cells.

Original languageHungarian
Pages (from-to)227-231
Number of pages5
JournalOrvosi Hetilap
Volume137
Issue number5
Publication statusPublished - Feb 4 1996

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Chromosome Aberrations
Acute Myeloid Leukemia
Down Syndrome
Chromosomes, Human, Pair 8
Polyploidy
Wilms Tumor
Karyotype
Neoplasms
Leukemia
Chromosomes
Mothers

ASJC Scopus subject areas

  • Medicine(all)

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A veleszületett kromoszóma-rendellenességek és a malignus megbetegedések társulása. / Erzsébet, B.; Andrea, N.; Róbert, S.; Oláh, E.

In: Orvosi Hetilap, Vol. 137, No. 5, 04.02.1996, p. 227-231.

Research output: Contribution to journalArticle

Erzsébet, B, Andrea, N, Róbert, S & Oláh, E 1996, 'A veleszületett kromoszóma-rendellenességek és a malignus megbetegedések társulása.', Orvosi Hetilap, vol. 137, no. 5, pp. 227-231.
Erzsébet, B. ; Andrea, N. ; Róbert, S. ; Oláh, E. / A veleszületett kromoszóma-rendellenességek és a malignus megbetegedések társulása. In: Orvosi Hetilap. 1996 ; Vol. 137, No. 5. pp. 227-231.
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