Relationship between hepatitis C virus (HCV) infection and lichen planus (LP) is well known but controversial in the literature. Aim: Two patients with lichen planus and chronic hepatitis C have been presented. One of them suffered with disseminated LP and the other had cutaneous and oral erosive symptoms. Methods: The chronic hepatitis of the patients was proved by elevated ALT and AST level, anti HCV (ELISA) and HCV-PCR serological examinations and liver biopsy. The diagnosis of lichen planus established on he typical clinical symptoms and the histological examination. Results: HCV RNA in the skin specimen from the biopsy of the skin lesion was detected by RT-PCR method, but the non affected skin specimen from the first patient was HCV RNA negative. Treatment of the chronic hepatitis C with specific therapy (interferon-alpha + ribavirine) in the second patient led to the regression of lichen planus symptoms. Conclusions: The authors supposed that the lichen planus is one of the extrahepatic manifestations of HCV infection and there is a real correlation between the two diseases in authors cases.
|Number of pages||4|
|Publication status||Published - Mar 26 2006|
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