Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men

David M. Lee, Dirk Vanderschueren, Steven Boonen, Terence W. O'Neill, Neil Pendleton, Stephen R. Pye, Rathi Ravindrarajah, Evelien Gielen, Frank Claessens, György Bartfai, Felipe F. Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Michael E.J. Lean, Margus Punab, Frederick C.W. WuLuisa Petrone, Giovanni Corona, Herman Borghs, Jolanta Slowikowska-Hilczer, Renata Walczak-Jedrzejowska, Philip Steer, Emma Carter, Felipe Casanueva, Ana I. Castro, Imre Földesi, Imre Fejes, Paul Korrovitz, Min Jiang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: vitamin D deficiency has been associated with an increased risk of mortality, but whether this relationship is causal or linked to co-existent comorbidity and adverse life factors remains uncertain. Our objective was to determine whether endogenous 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D) and parathyroid hormone (PTH) levels predicted all-cause, cardiovascular and cancer mortality independently of health and lifestyle factors. Setting: prospective cohort analysis within the European Male Ageing Study. Participants: 2,816 community-dwelling men aged 40-79 years at baseline. Methods: Cox regression was used to examine the association of all-cause mortality with 25(OH)D, 1,25(OH)2D and PTH; cardiovascular and cancer mortality were modelled using competing-risks regression. Results were expressed as hazard ratios (HR) and 95% confidence intervals (CIs) for Cox models; subhazard ratios (SHR) and 95% CIs for competing-risks models. Results: a total of 187 men died during a median of 4.3 years of follow-up. Serum levels of 25(OH)D (per 1 SD decrease: HR = 1.45; 95% CI = 1.16, 1.81) and 1,25(OH)2D (per 1 SD decrease: HR = 1.20; 95% CI = 1.00, 1.44) were associated with an increased risk of all-cause mortality after adjusting for age, centre, smoking, self-reported morbidities, physical activity and functional performance. Only levels of 25(OH)D <25 nmol/l predicted cancer mortality (SHR = 3.33; 95% CI = 1.38, 8.04). Conclusion: lower 25(OH)D and 1,25(OH)2D levels independently predicted all-cause mortality in middle-aged and older European men. Associations with cancer mortality were only observed among men with very low levels of 25(OH)D. These associations were only partially explained by the range of adverse health and lifestyle factors measured here.

Original languageEnglish
Article numberaft206
Pages (from-to)528-535
Number of pages8
JournalAge and Ageing
Volume43
Issue number4
DOIs
Publication statusPublished - Jul 2014

Keywords

  • 1,25-dihydroxyvitamin D
  • 25-Hydroxyvitamin D
  • Mortality
  • Older people
  • Parathyroid hormone
  • Population based

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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    Lee, D. M., Vanderschueren, D., Boonen, S., O'Neill, T. W., Pendleton, N., Pye, S. R., Ravindrarajah, R., Gielen, E., Claessens, F., Bartfai, G., Casanueva, F. F., Finn, J. D., Forti, G., Giwercman, A., Han, T. S., Huhtaniemi, I. T., Kula, K., Lean, M. E. J., Punab, M., ... Jiang, M. (2014). Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men. Age and Ageing, 43(4), 528-535. [aft206]. https://doi.org/10.1093/ageing/aft206