Association between VEGF Gene Polymorphisms and In-Stent Restenosis after Coronary Intervention Treated with Bare Metal Stent

Zsolt Bagyura, Loretta Kiss, Kristóf Hirschberg, Balázs Berta, G. Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, B. Merkely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. In-stent restenosis (ISR) is the gradual narrowing of the vessel lumen after coronary stent implantation due to the increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role in this process. Our aim was to analyze the association of single nucleotide polymorphisms of the VEGF gene (rs2010963 and rs6999447) with the occurrence of ISR after coronary artery bare metal stent (BMS) implantation. Methods. 205 patients with a history of BMS implantation and a repeated coronarography were prospectively enrolled. Patients were assigned to diffuse restenosis group (n=105) and control group (n=100) and VEGF genotypes were determined. Results. Diffuse ISR was significantly more frequently observed in patients with homozygous normal genotype of rs2010963 polymorphism, and this polymorphism was independently associated with diffuse ISR. Conclusions. RS2010963 is associated with higher incidence of development of diffuse coronary ISR in patients treated with BMS implantation.

Original languageEnglish
Article number9548612
JournalDisease Markers
Volume2017
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Coronary Restenosis
Stents
Polymorphism
Vascular Endothelial Growth Factor A
Genes
Metals
Genotype
Cell proliferation
Vascular Smooth Muscle
Smooth Muscle Myocytes
Single Nucleotide Polymorphism
Muscle
Coronary Vessels
Nucleotides
Cell Proliferation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Association between VEGF Gene Polymorphisms and In-Stent Restenosis after Coronary Intervention Treated with Bare Metal Stent. / Bagyura, Zsolt; Kiss, Loretta; Hirschberg, Kristóf; Berta, Balázs; Széplaki, G.; Lux, Árpád; Szelid, Zsolt; Soós, Pál; Merkely, B.

In: Disease Markers, Vol. 2017, 9548612, 01.01.2017.

Research output: Contribution to journalArticle

Bagyura, Zsolt ; Kiss, Loretta ; Hirschberg, Kristóf ; Berta, Balázs ; Széplaki, G. ; Lux, Árpád ; Szelid, Zsolt ; Soós, Pál ; Merkely, B. / Association between VEGF Gene Polymorphisms and In-Stent Restenosis after Coronary Intervention Treated with Bare Metal Stent. In: Disease Markers. 2017 ; Vol. 2017.
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AU - Bagyura, Zsolt

AU - Kiss, Loretta

AU - Hirschberg, Kristóf

AU - Berta, Balázs

AU - Széplaki, G.

AU - Lux, Árpád

AU - Szelid, Zsolt

AU - Soós, Pál

AU - Merkely, B.

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