Association between uterus uni/bicornis in pregnant women and postural deformities in their offspring

E. Czeizel, E. Puhó, Abdallah Dakhlaoiu, F. Bánhidy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: The objective of the investigation was to study the possible association between uterus uni- or bicornis in pregnant women and structural birth defects (ie, congenital abnormalities) in their offspring. Study Design: There were 22,843 cases with congenital abnormality recorded in the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. These subjects were matched to 38,151 controls without any defect. Prevalence of medically recorded uterus uni/bicornis in the prenatal maternity logbook in the mothers of subjects with different congenital abnormalities and of their matched controls without any defect were compared. Results: Fifty-seven (0.25%) subjects and 67 (0.18%) controls had mothers with uterus uni/bicornis. There was a significant association of uterus uni/bicornis in pregnant women with a higher risk of total group of congenital abnormalities (adjusted odds ratio, 1.5; 95% confidence interval, 1.12.2) explained mainly by a significantly higher risk of clubfoot and particularly postural deformity association in their children (adjusted odds ratio, 4.7; 95% confidence interval, 2.49.1). Conclusion: Pregnant women with a uni/bicornis uterus have a significantly higher risk of clubfoot and postural deformity association.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Uterus
Pregnant Women
Clubfoot
Odds Ratio
Mothers
Confidence Intervals

Keywords

  • clubfoot
  • congenital abnormalities
  • low birthweight
  • postural deformity association
  • preterm birth
  • uterus uni- or bicornis in pregnant women

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Association between uterus uni/bicornis in pregnant women and postural deformities in their offspring",
abstract = "Objective: The objective of the investigation was to study the possible association between uterus uni- or bicornis in pregnant women and structural birth defects (ie, congenital abnormalities) in their offspring. Study Design: There were 22,843 cases with congenital abnormality recorded in the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. These subjects were matched to 38,151 controls without any defect. Prevalence of medically recorded uterus uni/bicornis in the prenatal maternity logbook in the mothers of subjects with different congenital abnormalities and of their matched controls without any defect were compared. Results: Fifty-seven (0.25{\%}) subjects and 67 (0.18{\%}) controls had mothers with uterus uni/bicornis. There was a significant association of uterus uni/bicornis in pregnant women with a higher risk of total group of congenital abnormalities (adjusted odds ratio, 1.5; 95{\%} confidence interval, 1.12.2) explained mainly by a significantly higher risk of clubfoot and particularly postural deformity association in their children (adjusted odds ratio, 4.7; 95{\%} confidence interval, 2.49.1). Conclusion: Pregnant women with a uni/bicornis uterus have a significantly higher risk of clubfoot and postural deformity association.",
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