Association between the Malnutrition-Inflammation Score and depressive symptoms in kidney transplanted patients

Maria E. Czira, Anett V. Lindner, L. Szeifert, M. Molnár, Katalin Fornadi, Andrea Kelemen, Gergely Laszlo, I. Mucsi, Andras P. Keszei, Sidney H. Kennedy, M. Novák

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: Depressive symptoms and the Malnutrition-Inflammation Complex Syndrome (MICS) are prevalent in patients with chronic kidney disease. The complex relationship between MICS and depression has never been studied in kidney transplanted (Tx) patients. Here we evaluate the association between the Malnutrition-Inflammation Score (MIS) (Kalantar score) and depressive symptoms in Tx patients. Methods: Cross-sectional data of 973 prevalent Tx patients were analyzed. Sociodemographic and anthropometric characteristics and clinical and laboratory data were collected, and serum levels of inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-Α)] were measured. The Center for Epidemiologic Studies-Depression (CES-D) scale, the MIS and the Charlson Comorbidity Index (CCI) were computed. We used linear regression analysis to examine whether the relationship between MIS and CES-D score is independent from sociodemographic and laboratory parameters. Results: The CES-D score, corrected for age, gender and estimated glomerular filtration rate weakly but significantly correlated with serum IL-6 and the CCI (0.124 and 0.103, respectively; P

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalGeneral Hospital Psychiatry
Volume33
Issue number2
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Malnutrition
Depression
Inflammation
Kidney
Epidemiologic Studies
Comorbidity
Interleukin-6
Serum
Glomerular Filtration Rate
Chronic Renal Insufficiency
C-Reactive Protein
Linear Models
Tumor Necrosis Factor-alpha
Regression Analysis

Keywords

  • Depression
  • Inflammation
  • Kidney transplant
  • Malnutrition
  • Malnutrition-Inflammation Score

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Association between the Malnutrition-Inflammation Score and depressive symptoms in kidney transplanted patients. / Czira, Maria E.; Lindner, Anett V.; Szeifert, L.; Molnár, M.; Fornadi, Katalin; Kelemen, Andrea; Laszlo, Gergely; Mucsi, I.; Keszei, Andras P.; Kennedy, Sidney H.; Novák, M.

In: General Hospital Psychiatry, Vol. 33, No. 2, 03.2011, p. 157-165.

Research output: Contribution to journalArticle

Czira, Maria E. ; Lindner, Anett V. ; Szeifert, L. ; Molnár, M. ; Fornadi, Katalin ; Kelemen, Andrea ; Laszlo, Gergely ; Mucsi, I. ; Keszei, Andras P. ; Kennedy, Sidney H. ; Novák, M. / Association between the Malnutrition-Inflammation Score and depressive symptoms in kidney transplanted patients. In: General Hospital Psychiatry. 2011 ; Vol. 33, No. 2. pp. 157-165.
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