Association between the Epstein-Barr virus and Hodgkin's lymphoma in the north-eastern part of Hungary: Effects on therapy and survival

Katalin Keresztes, Zsofia Miltenyi, Beata Bessenyei, Zoltan Beck, Zoltan Szollosi, Z. Nemes, E. Oláh, A. Illés

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Abstract

This retrospective study included 109 patients with Hodgkin's lymphoma (HL; 45 females, 64 males). In 47 of the 109 HL patients (43%), immunohistochemical analysis of their formalin-fixed, paraffin-embedded histologie samples revealed Epstein-Barr virus (EBV) by latent membrane protein (LMP) 1. The highest virus association (50%) was found with the mixed cellularity histologic subtype, especially in patients aged 11-20 and >50 years. Virus positivity in nodular sclerosis was 35% (negative cases accumulated in patients aged 15-30 years). Regarding clinical stages, histologic subtypes, general symptoms, treatments employed and response to treatment, the EBV-positive group was not significantly different from the virus-negative group. During the mean follow-up time of 83 months (9-300 months), the overall or event-free survival of EBV-negative patients was more favorable than that of EBV-positive patients, although the difference was not significant (p = 0.16 and p = 0.24, respectively). EBV infection may be involved in the pathogenesis of HL in our Hungarian study cohort, but it does not significantly affect clinical symptoms, therapeutic results or complete and event-free survival of HL patients.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalActa Haematologica
Volume116
Issue number2
DOIs
Publication statusPublished - Aug 2006

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Hungary
Human Herpesvirus 4
Hodgkin Disease
Survival
Viruses
Therapeutics
Disease-Free Survival
Epstein-Barr Virus Infections
Sclerosis
Paraffin
Formaldehyde
Cohort Studies
Retrospective Studies

Keywords

  • Epstein-Barr
  • Hodgkin's lymphoma
  • Survival

ASJC Scopus subject areas

  • Hematology

Cite this

Association between the Epstein-Barr virus and Hodgkin's lymphoma in the north-eastern part of Hungary : Effects on therapy and survival. / Keresztes, Katalin; Miltenyi, Zsofia; Bessenyei, Beata; Beck, Zoltan; Szollosi, Zoltan; Nemes, Z.; Oláh, E.; Illés, A.

In: Acta Haematologica, Vol. 116, No. 2, 08.2006, p. 101-107.

Research output: Contribution to journalArticle

Keresztes, Katalin ; Miltenyi, Zsofia ; Bessenyei, Beata ; Beck, Zoltan ; Szollosi, Zoltan ; Nemes, Z. ; Oláh, E. ; Illés, A. / Association between the Epstein-Barr virus and Hodgkin's lymphoma in the north-eastern part of Hungary : Effects on therapy and survival. In: Acta Haematologica. 2006 ; Vol. 116, No. 2. pp. 101-107.
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