Association between novelty seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene

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Abstract

Association between the human personality trait 'Novelty Seeking' and the polymorphism of the DRD4 gene was first reported by Ebstein and Benjamin in 1996. This was soon followed by replication studies in various ethnic groups and by studying the role of other neuro-transmitter receptor and transporter genes in the genetic determination of human temperament. More recently, several polymorphic sites of the upstream regulatory region of the DRD4 gene have been described. Among these the -521 C/T single nucleotide polymorphism (SNP) was shown to be associated with the Novelty Seeking (NS) scores of the Temperament and Character Inventory (TCI) in a Japanese male population. We have investigated the -521 C/T SNP polymorphism in a Caucasian (Hungarian) population, and here we report a replication of the Japanese findings, in an association study involving 109 healthy Hungarian volunteers. We found a weak association between NS and CC vs CT or TT genotypes (P <0.06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P <0.01), but showed no genotypic effect for males.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalMolecular Psychiatry
Volume6
Issue number1
DOIs
Publication statusPublished - 2001

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Genetic Promoter Regions
Temperament
Single Nucleotide Polymorphism
Genes
Nucleic Acid Regulatory Sequences
Medical Genetics
Ethnic Groups
Population
Personality
Healthy Volunteers
Genotype
Equipment and Supplies

Keywords

  • Dopamine
  • DRD4 promoter
  • Human personality
  • Novelty Seeking
  • Single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

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abstract = "Association between the human personality trait 'Novelty Seeking' and the polymorphism of the DRD4 gene was first reported by Ebstein and Benjamin in 1996. This was soon followed by replication studies in various ethnic groups and by studying the role of other neuro-transmitter receptor and transporter genes in the genetic determination of human temperament. More recently, several polymorphic sites of the upstream regulatory region of the DRD4 gene have been described. Among these the -521 C/T single nucleotide polymorphism (SNP) was shown to be associated with the Novelty Seeking (NS) scores of the Temperament and Character Inventory (TCI) in a Japanese male population. We have investigated the -521 C/T SNP polymorphism in a Caucasian (Hungarian) population, and here we report a replication of the Japanese findings, in an association study involving 109 healthy Hungarian volunteers. We found a weak association between NS and CC vs CT or TT genotypes (P <0.06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P <0.01), but showed no genotypic effect for males.",
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AU - Rónai, Z.

AU - Székely, A.

AU - Nemoda, Z.

AU - Lakatos, K.

AU - Gervai, J.

AU - Staub, M.

AU - Sasvári, M.

PY - 2001

Y1 - 2001

N2 - Association between the human personality trait 'Novelty Seeking' and the polymorphism of the DRD4 gene was first reported by Ebstein and Benjamin in 1996. This was soon followed by replication studies in various ethnic groups and by studying the role of other neuro-transmitter receptor and transporter genes in the genetic determination of human temperament. More recently, several polymorphic sites of the upstream regulatory region of the DRD4 gene have been described. Among these the -521 C/T single nucleotide polymorphism (SNP) was shown to be associated with the Novelty Seeking (NS) scores of the Temperament and Character Inventory (TCI) in a Japanese male population. We have investigated the -521 C/T SNP polymorphism in a Caucasian (Hungarian) population, and here we report a replication of the Japanese findings, in an association study involving 109 healthy Hungarian volunteers. We found a weak association between NS and CC vs CT or TT genotypes (P <0.06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P <0.01), but showed no genotypic effect for males.

AB - Association between the human personality trait 'Novelty Seeking' and the polymorphism of the DRD4 gene was first reported by Ebstein and Benjamin in 1996. This was soon followed by replication studies in various ethnic groups and by studying the role of other neuro-transmitter receptor and transporter genes in the genetic determination of human temperament. More recently, several polymorphic sites of the upstream regulatory region of the DRD4 gene have been described. Among these the -521 C/T single nucleotide polymorphism (SNP) was shown to be associated with the Novelty Seeking (NS) scores of the Temperament and Character Inventory (TCI) in a Japanese male population. We have investigated the -521 C/T SNP polymorphism in a Caucasian (Hungarian) population, and here we report a replication of the Japanese findings, in an association study involving 109 healthy Hungarian volunteers. We found a weak association between NS and CC vs CT or TT genotypes (P <0.06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P <0.01), but showed no genotypic effect for males.

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KW - Novelty Seeking

KW - Single nucleotide polymorphism (SNP)

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