A nikotin dependencia és a dopamin D4-es receptor -521 CT promoter polimorfizmusának asszociációja major depressziós betegcsoportban

Translated title of the contribution: Association between nicotine dependence and the -521 promoter polymorfism of the dopamine D4 receptor in patients with major depression

Eszter Kótyuk, Réka Kovács-Nagy, G. Faludi, R. Urbán, Z. Rónai, M. Sasvári, A. Székely

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Investigating initiation of smoking behavior and factors involved in developing nicotine dependence is an important health issue worldwide. Various environmental, psychological and genetic risk factors are studies in the background of this complex behavior. The self-medication hypothesis may account for the increased prevalence of smoking behavior and more pronounced nicotine dependence among psychiatric patients. The present study investigates smoking habit and dependence measures in 133 Caucasian patients diagnosed with major depression. Investigated categorical endophenotypes included of smoking behavior included non-smokers who never smoked (1), non-smokers who smoked previously (2), occasional present smokers (3), and regular present smokers (4). Dimensional endophenotypes of nicotine addiction have been characterized by Hungarian adaptations of the Hooked on Nicotine Checklist and the Fagerström Test for Nicotine Dependence. Polymorphic regions of the dopaminergic system have been included as candidate genetic factors including the repeat polymorphism in the III. Exon of the DRD4 (DRD4 VNTR), two promoter SNPs of this gene (-521 CT and -616CG), as well as the repeat polymorphism of the dopamine transporter (DAT VNTR) polymorphism and the Val/Met polymorphism of the catechol-O-methyltransferase (COMT) gene. No significant difference was found between the genotype distributions in the four categories of smoking behavior. However, a significant association is reported with nicotine addiction of patients with major depression using the dimensional approach: patients with the C allele showed lower average scores on the Nicotine Checklist (CC or CT: mean score=6.8±3.4) as compared to those without the C allele (TT: mean score=10.1±2.5), these differences were significant (p=0,003).

Original languageHungarian
Pages (from-to)59-67
Number of pages9
JournalNeuropsychopharmacologia Hungarica
Volume11
Issue number2
Publication statusPublished - 2009

Fingerprint

Dopamine D4 Receptors
Tobacco Use Disorder
Nicotine
Smoking
Depression
Endophenotypes
Checklist
Alleles
Catechol O-Methyltransferase
Self Medication
Dopamine Plasma Membrane Transport Proteins
Genes
Habits
Single Nucleotide Polymorphism
Psychiatry
Exons
Genotype
Psychology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

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title = "A nikotin dependencia {\'e}s a dopamin D4-es receptor -521 CT promoter polimorfizmus{\'a}nak asszoci{\'a}ci{\'o}ja major depresszi{\'o}s betegcsoportban",
abstract = "Investigating initiation of smoking behavior and factors involved in developing nicotine dependence is an important health issue worldwide. Various environmental, psychological and genetic risk factors are studies in the background of this complex behavior. The self-medication hypothesis may account for the increased prevalence of smoking behavior and more pronounced nicotine dependence among psychiatric patients. The present study investigates smoking habit and dependence measures in 133 Caucasian patients diagnosed with major depression. Investigated categorical endophenotypes included of smoking behavior included non-smokers who never smoked (1), non-smokers who smoked previously (2), occasional present smokers (3), and regular present smokers (4). Dimensional endophenotypes of nicotine addiction have been characterized by Hungarian adaptations of the Hooked on Nicotine Checklist and the Fagerstr{\"o}m Test for Nicotine Dependence. Polymorphic regions of the dopaminergic system have been included as candidate genetic factors including the repeat polymorphism in the III. Exon of the DRD4 (DRD4 VNTR), two promoter SNPs of this gene (-521 CT and -616CG), as well as the repeat polymorphism of the dopamine transporter (DAT VNTR) polymorphism and the Val/Met polymorphism of the catechol-O-methyltransferase (COMT) gene. No significant difference was found between the genotype distributions in the four categories of smoking behavior. However, a significant association is reported with nicotine addiction of patients with major depression using the dimensional approach: patients with the C allele showed lower average scores on the Nicotine Checklist (CC or CT: mean score=6.8±3.4) as compared to those without the C allele (TT: mean score=10.1±2.5), these differences were significant (p=0,003).",
keywords = "-521 CT SNP, Candidate gene study, Dopamine D4 receptor, Major depression, Nicotine dependence, Smoking",
author = "Eszter K{\'o}tyuk and R{\'e}ka Kov{\'a}cs-Nagy and G. Faludi and R. Urb{\'a}n and Z. R{\'o}nai and M. Sasv{\'a}ri and A. Sz{\'e}kely",
year = "2009",
language = "Hungarian",
volume = "11",
pages = "59--67",
journal = "Neuropsychopharmacologia Hungarica",
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TY - JOUR

T1 - A nikotin dependencia és a dopamin D4-es receptor -521 CT promoter polimorfizmusának asszociációja major depressziós betegcsoportban

AU - Kótyuk, Eszter

AU - Kovács-Nagy, Réka

AU - Faludi, G.

AU - Urbán, R.

AU - Rónai, Z.

AU - Sasvári, M.

AU - Székely, A.

PY - 2009

Y1 - 2009

N2 - Investigating initiation of smoking behavior and factors involved in developing nicotine dependence is an important health issue worldwide. Various environmental, psychological and genetic risk factors are studies in the background of this complex behavior. The self-medication hypothesis may account for the increased prevalence of smoking behavior and more pronounced nicotine dependence among psychiatric patients. The present study investigates smoking habit and dependence measures in 133 Caucasian patients diagnosed with major depression. Investigated categorical endophenotypes included of smoking behavior included non-smokers who never smoked (1), non-smokers who smoked previously (2), occasional present smokers (3), and regular present smokers (4). Dimensional endophenotypes of nicotine addiction have been characterized by Hungarian adaptations of the Hooked on Nicotine Checklist and the Fagerström Test for Nicotine Dependence. Polymorphic regions of the dopaminergic system have been included as candidate genetic factors including the repeat polymorphism in the III. Exon of the DRD4 (DRD4 VNTR), two promoter SNPs of this gene (-521 CT and -616CG), as well as the repeat polymorphism of the dopamine transporter (DAT VNTR) polymorphism and the Val/Met polymorphism of the catechol-O-methyltransferase (COMT) gene. No significant difference was found between the genotype distributions in the four categories of smoking behavior. However, a significant association is reported with nicotine addiction of patients with major depression using the dimensional approach: patients with the C allele showed lower average scores on the Nicotine Checklist (CC or CT: mean score=6.8±3.4) as compared to those without the C allele (TT: mean score=10.1±2.5), these differences were significant (p=0,003).

AB - Investigating initiation of smoking behavior and factors involved in developing nicotine dependence is an important health issue worldwide. Various environmental, psychological and genetic risk factors are studies in the background of this complex behavior. The self-medication hypothesis may account for the increased prevalence of smoking behavior and more pronounced nicotine dependence among psychiatric patients. The present study investigates smoking habit and dependence measures in 133 Caucasian patients diagnosed with major depression. Investigated categorical endophenotypes included of smoking behavior included non-smokers who never smoked (1), non-smokers who smoked previously (2), occasional present smokers (3), and regular present smokers (4). Dimensional endophenotypes of nicotine addiction have been characterized by Hungarian adaptations of the Hooked on Nicotine Checklist and the Fagerström Test for Nicotine Dependence. Polymorphic regions of the dopaminergic system have been included as candidate genetic factors including the repeat polymorphism in the III. Exon of the DRD4 (DRD4 VNTR), two promoter SNPs of this gene (-521 CT and -616CG), as well as the repeat polymorphism of the dopamine transporter (DAT VNTR) polymorphism and the Val/Met polymorphism of the catechol-O-methyltransferase (COMT) gene. No significant difference was found between the genotype distributions in the four categories of smoking behavior. However, a significant association is reported with nicotine addiction of patients with major depression using the dimensional approach: patients with the C allele showed lower average scores on the Nicotine Checklist (CC or CT: mean score=6.8±3.4) as compared to those without the C allele (TT: mean score=10.1±2.5), these differences were significant (p=0,003).

KW - -521 CT SNP

KW - Candidate gene study

KW - Dopamine D4 receptor

KW - Major depression

KW - Nicotine dependence

KW - Smoking

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