Association between long-term kidney graft survival and the presence of pre-transplant cytotoxic anti-HLA and/or non-MHC 'FcγRII blocking' (anti-TLX) alloantibody

Ágnes Padányi, Éva Gyódi, K. Rajczy, F. Perner, G. Petrányi

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5 Citations (Scopus)

Abstract

One hundred kidney graft recipients were analysed retrospectively with regard to the presence of FcγRII (EAI) blocking or cytotoxic HLA antibody induced by pretransplant transfusion. Previous studies suggested that transfusion induces the production of EAI blocking antibody which may have specificity to TLX/CD46/MCP alloantigens. A superior graft survival (65%/ 9 yr) was found in the presence of EAI alloantibody compared to graft survival in the absence of this antibody (40%/ 9 yr). Further analysis showed the following survival rates in relation to the combined appearance of HLA cytotoxic and EAI antibody (EAI positive, HLA negative 67%/ 9 yr; EAI positive, HLA positive 60%/ 9 yr; EAI negative, HLA positive 0%/ 9 yr; EAI negative, HLA negative 40%/ 9 yr). There was striking low graft failure in the first 6 months in patients with EAI antibody. Taking into consideration that the HLA B/DR mismatching grade in all various groups were the same and no considerable difference was found in association to graft survival, the presence or absence of αEAI (anti-TLX) antibody solely seems to have superior or additional effect on graft survival as compared to HLA matching.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalClinical Transplantation
Volume10
Issue number5
Publication statusPublished - 1996

Fingerprint

Isoantibodies
Graft Survival
Transplants
Kidney
Antibodies
Blocking Antibodies
HLA-B Antigens
Isoantigens
HLA-DR Antigens
Anti-Idiotypic Antibodies
Survival Rate

Keywords

  • Alloantibody
  • Immunoregulation
  • Kidney transplant
  • Transfusion effect

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

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title = "Association between long-term kidney graft survival and the presence of pre-transplant cytotoxic anti-HLA and/or non-MHC 'FcγRII blocking' (anti-TLX) alloantibody",
abstract = "One hundred kidney graft recipients were analysed retrospectively with regard to the presence of FcγRII (EAI) blocking or cytotoxic HLA antibody induced by pretransplant transfusion. Previous studies suggested that transfusion induces the production of EAI blocking antibody which may have specificity to TLX/CD46/MCP alloantigens. A superior graft survival (65{\%}/ 9 yr) was found in the presence of EAI alloantibody compared to graft survival in the absence of this antibody (40{\%}/ 9 yr). Further analysis showed the following survival rates in relation to the combined appearance of HLA cytotoxic and EAI antibody (EAI positive, HLA negative 67{\%}/ 9 yr; EAI positive, HLA positive 60{\%}/ 9 yr; EAI negative, HLA positive 0{\%}/ 9 yr; EAI negative, HLA negative 40{\%}/ 9 yr). There was striking low graft failure in the first 6 months in patients with EAI antibody. Taking into consideration that the HLA B/DR mismatching grade in all various groups were the same and no considerable difference was found in association to graft survival, the presence or absence of αEAI (anti-TLX) antibody solely seems to have superior or additional effect on graft survival as compared to HLA matching.",
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author = "{\'A}gnes Pad{\'a}nyi and {\'E}va Gy{\'o}di and K. Rajczy and F. Perner and G. Petr{\'a}nyi",
year = "1996",
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AU - Padányi, Ágnes

AU - Gyódi, Éva

AU - Rajczy, K.

AU - Perner, F.

AU - Petrányi, G.

PY - 1996

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N2 - One hundred kidney graft recipients were analysed retrospectively with regard to the presence of FcγRII (EAI) blocking or cytotoxic HLA antibody induced by pretransplant transfusion. Previous studies suggested that transfusion induces the production of EAI blocking antibody which may have specificity to TLX/CD46/MCP alloantigens. A superior graft survival (65%/ 9 yr) was found in the presence of EAI alloantibody compared to graft survival in the absence of this antibody (40%/ 9 yr). Further analysis showed the following survival rates in relation to the combined appearance of HLA cytotoxic and EAI antibody (EAI positive, HLA negative 67%/ 9 yr; EAI positive, HLA positive 60%/ 9 yr; EAI negative, HLA positive 0%/ 9 yr; EAI negative, HLA negative 40%/ 9 yr). There was striking low graft failure in the first 6 months in patients with EAI antibody. Taking into consideration that the HLA B/DR mismatching grade in all various groups were the same and no considerable difference was found in association to graft survival, the presence or absence of αEAI (anti-TLX) antibody solely seems to have superior or additional effect on graft survival as compared to HLA matching.

AB - One hundred kidney graft recipients were analysed retrospectively with regard to the presence of FcγRII (EAI) blocking or cytotoxic HLA antibody induced by pretransplant transfusion. Previous studies suggested that transfusion induces the production of EAI blocking antibody which may have specificity to TLX/CD46/MCP alloantigens. A superior graft survival (65%/ 9 yr) was found in the presence of EAI alloantibody compared to graft survival in the absence of this antibody (40%/ 9 yr). Further analysis showed the following survival rates in relation to the combined appearance of HLA cytotoxic and EAI antibody (EAI positive, HLA negative 67%/ 9 yr; EAI positive, HLA positive 60%/ 9 yr; EAI negative, HLA positive 0%/ 9 yr; EAI negative, HLA negative 40%/ 9 yr). There was striking low graft failure in the first 6 months in patients with EAI antibody. Taking into consideration that the HLA B/DR mismatching grade in all various groups were the same and no considerable difference was found in association to graft survival, the presence or absence of αEAI (anti-TLX) antibody solely seems to have superior or additional effect on graft survival as compared to HLA matching.

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KW - Transfusion effect

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