Association between hypnotizability and the catechol-O-methyltransferase (COMT) polymorphism

Anna Szekely, Reka Kovacs-Nagy, Eva I. Banyai, Anna C. Gösi-Greguss, Katalin Varga, Zsuzsa Halmai, Zsolt Ronai, Maria Sasvari-Szekely

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34 Citations (Scopus)


Previous studies implicate involvement of dopaminergic systems in hypnotizability and report association with the COMT Val158Met single nucleotide polymorphism (SNP, rs4680) demonstrating the Val/Met heterozygotes as the most hypnotizable group using the Stanford Hypnotic Susceptibility Scale. This study replicates that association using an independent sample of 127 healthy Hungarian young adults and the Waterloo-Stanford Group C Scale of Hypnotic Susceptibility. Significant association (p =.016) was found between the COMT genotypes and hypnotizability, with a clear additive effect of the Val allele: Hypnotizability scores were highest in Val/Val (5.9), intermediate in Val/Met (4.7), and lowest in Met/Met (4.1). Differences between these results and those of previous studies support recent findings suggesting an inverted-U-shaped relation between dopamine level in the prefrontal cortex and cognitive functioning. The present study replicates association of COMT Val158Met SNP and hypnotizability and stresses the importance of mediating factors, such as group vs. individual inductions.

Original languageEnglish
Pages (from-to)301-315
Number of pages15
JournalInternational Journal of Clinical and Experimental Hypnosis
Issue number3
Publication statusPublished - Jul 1 2010

ASJC Scopus subject areas

  • Complementary and Manual Therapy
  • Clinical Psychology

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