Association between high platelet MAO activity and response to MAO inhibitor in depressed bipolars: Case reports

Z. Rihmer, M. Arato, G. Bagdy

Research output: Contribution to journalArticle

2 Citations (Scopus)


The authors describe two female patients with bipolar I depression who did not respond to tricyclic antidepressants in their previous depressive episodes and were prophylactic lithium nonresponders. Both patients showed a high pretreatment platelet MAO activity and responded well and rapidly to monoamine oxidase inhibition (MAOI) treatment. These findings suggest that although bipolar depressed patients show a low platelet MAO activity, there may be a subgroup with high enzyme activity. These patients revealed a low tendency to respond to tricyclic antidepressants and showed rapid improvement on MAOI therapy.

Original languageEnglish
Pages (from-to)119-120
Number of pages2
Issue number4
Publication statusPublished - Jan 1 1983


ASJC Scopus subject areas

  • Medicine(all)

Cite this