Association between G-308 A polymorphism of the tumor necrosis factor-α gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents

Dóra Krikovszky, B. Vásárhelyi, P. Tóth-Heyn, A. Körner, T. Tulassay, L. Madácsy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine, which also influences blood pressure (BP). The G-308 A polymorphism of the TNF-α gene is associated with altered TNF-α production. The prevalence of the TNF-α -308 A allele is reportedly higher among patients with type 1 diabetes mellitus (T1DM) than in the healthy population. In this study we investigated whether this genetic polymorphism might correlate with BP values in diabetic adolescents. Ambulatory BP monitoring (ABPM) was performed in 126 adolescents with T1DM (mean age: 14 ± 2.4 years). The TNF-α G-308 A genotype was determined by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methodologies. ABPM results were related to healthy reference values and are given as standard deviation score (SDS). The prevalence of the -308 A allele was higher in diabetic adolescents than the Hungarian reference population (0.26 vs 0.14, p -308GG and -308GA/AA genotypes, the 24-h systolic BP average values were 0.37 ± 1.33 and -0.38 ± 1.28 SDS, while 24-h diastolic BP average values were 0.09 ± 1.30 and -0.67 ± 1.31 SDS. Hence, the TNF-α -308 A allele carrier state appears to be associated with lower systolic and diastolic BP values.

Original languageEnglish
Pages (from-to)474-477
Number of pages4
JournalClinical Genetics
Volume62
Issue number6
DOIs
Publication statusPublished - Dec 1 2002

Fingerprint

Tumor Necrosis Factor-alpha
Blood Pressure
Genes
Alleles
Type 1 Diabetes Mellitus
Genotype
Carrier State
Ambulatory Monitoring
Ambulatory Blood Pressure Monitoring
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Population
Reference Values
Cytokines
Polymerase Chain Reaction

Keywords

  • Ambulatory blood pressure monitoring
  • Genetic polymorphism
  • Tumor necrosis factor-α
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

@article{d5fa9894b21749ba8dc5586deea828fa,
title = "Association between G-308 A polymorphism of the tumor necrosis factor-α gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents",
abstract = "Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine, which also influences blood pressure (BP). The G-308 A polymorphism of the TNF-α gene is associated with altered TNF-α production. The prevalence of the TNF-α -308 A allele is reportedly higher among patients with type 1 diabetes mellitus (T1DM) than in the healthy population. In this study we investigated whether this genetic polymorphism might correlate with BP values in diabetic adolescents. Ambulatory BP monitoring (ABPM) was performed in 126 adolescents with T1DM (mean age: 14 ± 2.4 years). The TNF-α G-308 A genotype was determined by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methodologies. ABPM results were related to healthy reference values and are given as standard deviation score (SDS). The prevalence of the -308 A allele was higher in diabetic adolescents than the Hungarian reference population (0.26 vs 0.14, p -308GG and -308GA/AA genotypes, the 24-h systolic BP average values were 0.37 ± 1.33 and -0.38 ± 1.28 SDS, while 24-h diastolic BP average values were 0.09 ± 1.30 and -0.67 ± 1.31 SDS. Hence, the TNF-α -308 A allele carrier state appears to be associated with lower systolic and diastolic BP values.",
keywords = "Ambulatory blood pressure monitoring, Genetic polymorphism, Tumor necrosis factor-α, Type 1 diabetes mellitus",
author = "D{\'o}ra Krikovszky and B. V{\'a}s{\'a}rhelyi and P. T{\'o}th-Heyn and A. K{\"o}rner and T. Tulassay and L. Mad{\'a}csy",
year = "2002",
month = "12",
day = "1",
doi = "10.1034/j.1399-0004.2002.620609.x",
language = "English",
volume = "62",
pages = "474--477",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Association between G-308 A polymorphism of the tumor necrosis factor-α gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents

AU - Krikovszky, Dóra

AU - Vásárhelyi, B.

AU - Tóth-Heyn, P.

AU - Körner, A.

AU - Tulassay, T.

AU - Madácsy, L.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine, which also influences blood pressure (BP). The G-308 A polymorphism of the TNF-α gene is associated with altered TNF-α production. The prevalence of the TNF-α -308 A allele is reportedly higher among patients with type 1 diabetes mellitus (T1DM) than in the healthy population. In this study we investigated whether this genetic polymorphism might correlate with BP values in diabetic adolescents. Ambulatory BP monitoring (ABPM) was performed in 126 adolescents with T1DM (mean age: 14 ± 2.4 years). The TNF-α G-308 A genotype was determined by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methodologies. ABPM results were related to healthy reference values and are given as standard deviation score (SDS). The prevalence of the -308 A allele was higher in diabetic adolescents than the Hungarian reference population (0.26 vs 0.14, p -308GG and -308GA/AA genotypes, the 24-h systolic BP average values were 0.37 ± 1.33 and -0.38 ± 1.28 SDS, while 24-h diastolic BP average values were 0.09 ± 1.30 and -0.67 ± 1.31 SDS. Hence, the TNF-α -308 A allele carrier state appears to be associated with lower systolic and diastolic BP values.

AB - Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine, which also influences blood pressure (BP). The G-308 A polymorphism of the TNF-α gene is associated with altered TNF-α production. The prevalence of the TNF-α -308 A allele is reportedly higher among patients with type 1 diabetes mellitus (T1DM) than in the healthy population. In this study we investigated whether this genetic polymorphism might correlate with BP values in diabetic adolescents. Ambulatory BP monitoring (ABPM) was performed in 126 adolescents with T1DM (mean age: 14 ± 2.4 years). The TNF-α G-308 A genotype was determined by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methodologies. ABPM results were related to healthy reference values and are given as standard deviation score (SDS). The prevalence of the -308 A allele was higher in diabetic adolescents than the Hungarian reference population (0.26 vs 0.14, p -308GG and -308GA/AA genotypes, the 24-h systolic BP average values were 0.37 ± 1.33 and -0.38 ± 1.28 SDS, while 24-h diastolic BP average values were 0.09 ± 1.30 and -0.67 ± 1.31 SDS. Hence, the TNF-α -308 A allele carrier state appears to be associated with lower systolic and diastolic BP values.

KW - Ambulatory blood pressure monitoring

KW - Genetic polymorphism

KW - Tumor necrosis factor-α

KW - Type 1 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=0036957894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036957894&partnerID=8YFLogxK

U2 - 10.1034/j.1399-0004.2002.620609.x

DO - 10.1034/j.1399-0004.2002.620609.x

M3 - Article

VL - 62

SP - 474

EP - 477

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 6

ER -