Association between estrogen receptor α (ESR1) gene polymorphisms and severe preeclampsia

Attila Molvarec, Ágota Vér, Andrea Fekete, Klára Rosta, Lázló Derzbach, Zoltán Derzsy, István Karádi, János Rigó

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Associations have been reported between estrogen receptor α (ESR1) gene polymorphisms and various pathological conditions, including cardiovascular diseases. Our aim was to investigate whether two polymorphisms of the ESR1 gene (ESR1 c.454 -397T>C: Pvull restriction site and c.454 -351A>G: Xbal restriction site) are associated with preeclampsia. In a case-control study, we analyzed blood samples from 119 severely preeclamptic patients and 103 normotensive, healthy pregnant women using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. All of the women were Caucasian. There was no association between severe preeclampsia and the Pvull and Xbal ESR1 gene polymorphisms separately. However, with the simultaneous carriage of both polymorphisms, the TT/AA genotype combination was significantly more frequent in severely preeclamptic patients than in healthy control subjects (24.4% vs. 9.7%, p=0.003), whereas the TT/AG combination was significantly less frequent in the severely preeclamptic group than in the control group (5.0% vs. 18.4%, p=0.002). According to the haplotype estimation, the homozygous T-A haplotype carriers had an increased risk of severe preeclampsia independent of maternal age, prepregnancy BMI, primiparity and smoking status (adjusted odds ratio [OR]: 4.36, 95% confidence interval [CI]: 1.65-11.53). The GG genotype of the Xbal polymorphism was associated with a lower risk of fetal growth restriction in patients with severe preeclampsia (OR: 0.23, 95% CI: 0.07-0.73). In conclusion, the homozygous T-A haplotype carriers of ESR1 Pvull and Xbal polymorphisms showed an increased risk of severe preeclampsia. In addition, the GG genotype of the Xbal polymorphism decreased the risk of fetal growth restriction in severely preeclamptic patients.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalHypertension Research
Volume30
Issue number3
DOIs
Publication statusPublished - Mar 1 2007

Keywords

  • Cardiovascular disease
  • Estrogen receptor
  • Gene
  • Polymorphism
  • Preeclampsia

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Association between estrogen receptor α (ESR1) gene polymorphisms and severe preeclampsia'. Together they form a unique fingerprint.

  • Cite this