Association between age and the 7 repeat allele of the dopamine D4 receptor gene

A. Székely, Eszter Kotyuk, Julianna Bircher, Andrea Vereczkei, David A. Balota, Maria Sasvari-Szekely, Z. Rónai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Longevity is in part (25%) inherited, and genetic studies aim to uncover allelic variants that play an important role in prolonging life span. Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66%) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90- 109 years old Californian centenarians, as compared to an ancestry-matched young population. In the present study we demonstrate the same association using continuous age groups in an 18-97 years old Caucasian sample (N = 1801, p = 0.007). We found a continuous pattern of increase from 18-75, however frequency of allele 7 carriers decreased in our oldest age groups. Possible role of gene-environment interaction effects driven by historical events are discussed. In accordance with previous findings, we observed association preferentially in females (p = 0.003). Our results underlie the importance of investigating nondisease related genetic variants as inherited components of longevity, and confirm, that the 7-repeat allele of the dopamine D4 receptor gene is a longevity enabling genetic factor, accumulating in the elderly female population.

Original languageEnglish
Article numbere0167753
JournalPLoS One
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Dopamine D4 Receptors
Genes
Alleles
alleles
genes
Minisatellite Repeats
Age Groups
Population
Gene-Environment Interaction
Polymorphism
Genome-Wide Association Study
Nucleotides
Gene Frequency
genotype-environment interaction
minisatellite repeats
Causality
Single Nucleotide Polymorphism
single nucleotide polymorphism
gene frequency
dopamine receptors

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Székely, A., Kotyuk, E., Bircher, J., Vereczkei, A., Balota, D. A., Sasvari-Szekely, M., & Rónai, Z. (2016). Association between age and the 7 repeat allele of the dopamine D4 receptor gene. PLoS One, 11(12), [e0167753]. https://doi.org/10.1371/journal.pone.0167753

Association between age and the 7 repeat allele of the dopamine D4 receptor gene. / Székely, A.; Kotyuk, Eszter; Bircher, Julianna; Vereczkei, Andrea; Balota, David A.; Sasvari-Szekely, Maria; Rónai, Z.

In: PLoS One, Vol. 11, No. 12, e0167753, 01.12.2016.

Research output: Contribution to journalArticle

Székely, A, Kotyuk, E, Bircher, J, Vereczkei, A, Balota, DA, Sasvari-Szekely, M & Rónai, Z 2016, 'Association between age and the 7 repeat allele of the dopamine D4 receptor gene', PLoS One, vol. 11, no. 12, e0167753. https://doi.org/10.1371/journal.pone.0167753
Székely A, Kotyuk E, Bircher J, Vereczkei A, Balota DA, Sasvari-Szekely M et al. Association between age and the 7 repeat allele of the dopamine D4 receptor gene. PLoS One. 2016 Dec 1;11(12). e0167753. https://doi.org/10.1371/journal.pone.0167753
Székely, A. ; Kotyuk, Eszter ; Bircher, Julianna ; Vereczkei, Andrea ; Balota, David A. ; Sasvari-Szekely, Maria ; Rónai, Z. / Association between age and the 7 repeat allele of the dopamine D4 receptor gene. In: PLoS One. 2016 ; Vol. 11, No. 12.
@article{4e6e4ce8203b4b5caef11ccde894d9e9,
title = "Association between age and the 7 repeat allele of the dopamine D4 receptor gene",
abstract = "Longevity is in part (25{\%}) inherited, and genetic studies aim to uncover allelic variants that play an important role in prolonging life span. Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66{\%}) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90- 109 years old Californian centenarians, as compared to an ancestry-matched young population. In the present study we demonstrate the same association using continuous age groups in an 18-97 years old Caucasian sample (N = 1801, p = 0.007). We found a continuous pattern of increase from 18-75, however frequency of allele 7 carriers decreased in our oldest age groups. Possible role of gene-environment interaction effects driven by historical events are discussed. In accordance with previous findings, we observed association preferentially in females (p = 0.003). Our results underlie the importance of investigating nondisease related genetic variants as inherited components of longevity, and confirm, that the 7-repeat allele of the dopamine D4 receptor gene is a longevity enabling genetic factor, accumulating in the elderly female population.",
author = "A. Sz{\'e}kely and Eszter Kotyuk and Julianna Bircher and Andrea Vereczkei and Balota, {David A.} and Maria Sasvari-Szekely and Z. R{\'o}nai",
year = "2016",
month = "12",
day = "1",
doi = "10.1371/journal.pone.0167753",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

TY - JOUR

T1 - Association between age and the 7 repeat allele of the dopamine D4 receptor gene

AU - Székely, A.

AU - Kotyuk, Eszter

AU - Bircher, Julianna

AU - Vereczkei, Andrea

AU - Balota, David A.

AU - Sasvari-Szekely, Maria

AU - Rónai, Z.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Longevity is in part (25%) inherited, and genetic studies aim to uncover allelic variants that play an important role in prolonging life span. Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66%) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90- 109 years old Californian centenarians, as compared to an ancestry-matched young population. In the present study we demonstrate the same association using continuous age groups in an 18-97 years old Caucasian sample (N = 1801, p = 0.007). We found a continuous pattern of increase from 18-75, however frequency of allele 7 carriers decreased in our oldest age groups. Possible role of gene-environment interaction effects driven by historical events are discussed. In accordance with previous findings, we observed association preferentially in females (p = 0.003). Our results underlie the importance of investigating nondisease related genetic variants as inherited components of longevity, and confirm, that the 7-repeat allele of the dopamine D4 receptor gene is a longevity enabling genetic factor, accumulating in the elderly female population.

AB - Longevity is in part (25%) inherited, and genetic studies aim to uncover allelic variants that play an important role in prolonging life span. Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66%) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90- 109 years old Californian centenarians, as compared to an ancestry-matched young population. In the present study we demonstrate the same association using continuous age groups in an 18-97 years old Caucasian sample (N = 1801, p = 0.007). We found a continuous pattern of increase from 18-75, however frequency of allele 7 carriers decreased in our oldest age groups. Possible role of gene-environment interaction effects driven by historical events are discussed. In accordance with previous findings, we observed association preferentially in females (p = 0.003). Our results underlie the importance of investigating nondisease related genetic variants as inherited components of longevity, and confirm, that the 7-repeat allele of the dopamine D4 receptor gene is a longevity enabling genetic factor, accumulating in the elderly female population.

UR - http://www.scopus.com/inward/record.url?scp=85006847227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006847227&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0167753

DO - 10.1371/journal.pone.0167753

M3 - Article

C2 - 27992450

AN - SCOPUS:85006847227

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e0167753

ER -