Association between a genetic variant of the alpha-7 nicotinic acetylcholine receptor subunit and four types of dementia

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Abstract

We tested the hypothesis whether the partially duplicated variant of α7 nicotinic acetylcholine receptor subunit gene (CHRFAM7A) 2-bp deletion (-2 bp) polymorphism and apolipoprotein E (ApoE) ε4 allele confer susceptibility to Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Pick's disease (PiD) and vascular dementia (VD). The study included 175 AD, 35 DLB patients, 38 PiD, 96 VD and 175 healthy control (HC) probands. The CHRFAM7A genotype without the -2 bp allele was significantly over-represented in AD (p = 0.011), DLB (p = 0.001) and PiD (p < 0.0001) compared to HC, but there were no statistical differences in VD (p = 0.407) compared to HC. We confirmed again that the ApoE ε4 allele is a risk factor for dementias. The -2 bp polymorphism of CHRFAM7A can be implicated in AD, DLB and PiD. However, it is unlikely that it plays an important role in the pathogenesis of VD.

Original languageEnglish
Pages (from-to)56-62
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume28
Issue number1
DOIs
Publication statusPublished - Aug 1 2009

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Dementia with Lewy bodies
  • Pick's disease
  • Vascular dementia
  • α7 nicotinic acetylcholine receptor

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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