Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men

David M. Lee, Abdelouahid Tajar, Aslan Ulubaev, Neil Pendleton, Terence W. O'Neill, Daryl B. O'Connor, G. Bártfai, Steven Boonen, Roger Bouillon, Felipe F. Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Michael E J Lean, Margus Punab, Alan J. Silman, Dirk Vanderschueren & 20 others Frederick C W Wu, Luisa Petrone, Antonio Cilotti, Herman Borghs, Jolanta Slowikowska-Hilczer, Renata Walczak-Jedrzejowska, Ilpo Huhtaniemi, Frederick Wu, Alan Silman, Terence O'Neill, Joseph Finn, Philip Steer, David Lee, Stephen Pye, Felipe Casanueva, Mary Lage, I. Földesi, I. Fejes, Paul Korrovitz, Min Jiang

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Background: Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men. Methods: This population-based cross-sectional study included 3,369 men aged 40-79 years from eight centres enrolled in the European Male Ageing Study. Cognitive function was assessed using the Rey-Osterrieth Complex Figure (ROCF) test, the Camden Topographical Recognition Memory (CTRM) test and the Digit Symbol Substitution Test (DSST). Serum 25(OH)D levels were measured by radioimmunoassay. Additional assessments included measurement of physical activity, functional performance and mood/depression. Associations between cognitive function and 25(OH)D levels were explored using locally weighted and linear regression models. Results: In total, 3,133 men (mean (±SD) age 60±11 years) were included in the analysis. The mean (±SD) 25(OH)D concentration was 63±31 nmol/l. In ageadjusted linear regressions, high levels of 25(OH)D were associated with high scores on the copy component of the ROCF test (β per 10 nmol/l=0.096; 95% CI 0.049 to 0.144), the CTRM test (β per 10 nmol/l=0.075; 95% CI 0.026 to 0.124) and the DSST (β per 10 nmol/l=0.318; 95% CI 0.235 to 0.401). After adjusting for additional confounders, 25(OH)D levels were associated with only score on the DSST (β per 10 nmol/l=0.152; 95% CI 0.051 to 0.253). Locally weighted and spline regressions suggested the relationship between 25(OH)D concentration and cognitive function was most pronounced at 25(OH)D concentrations below 35 nmol/l. Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.

Original languageEnglish
Pages (from-to)722-729
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume80
Issue number7
DOIs
Publication statusPublished - Jul 2009

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Cognition
Linear Models
Vitamin D
Radioimmunoassay
Cross-Sectional Studies
Outcome Assessment (Health Care)
Exercise
Depression
25-hydroxyvitamin D
Serum
Research
Population
Recognition (Psychology)

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery

Cite this

Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. / Lee, David M.; Tajar, Abdelouahid; Ulubaev, Aslan; Pendleton, Neil; O'Neill, Terence W.; O'Connor, Daryl B.; Bártfai, G.; Boonen, Steven; Bouillon, Roger; Casanueva, Felipe F.; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Lean, Michael E J; Punab, Margus; Silman, Alan J.; Vanderschueren, Dirk; Wu, Frederick C W; Petrone, Luisa; Cilotti, Antonio; Borghs, Herman; Slowikowska-Hilczer, Jolanta; Walczak-Jedrzejowska, Renata; Huhtaniemi, Ilpo; Wu, Frederick; Silman, Alan; O'Neill, Terence; Finn, Joseph; Steer, Philip; Lee, David; Pye, Stephen; Casanueva, Felipe; Lage, Mary; Földesi, I.; Fejes, I.; Korrovitz, Paul; Jiang, Min.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 80, No. 7, 07.2009, p. 722-729.

Research output: Contribution to journalArticle

Lee, DM, Tajar, A, Ulubaev, A, Pendleton, N, O'Neill, TW, O'Connor, DB, Bártfai, G, Boonen, S, Bouillon, R, Casanueva, FF, Finn, JD, Forti, G, Giwercman, A, Han, TS, Huhtaniemi, IT, Kula, K, Lean, MEJ, Punab, M, Silman, AJ, Vanderschueren, D, Wu, FCW, Petrone, L, Cilotti, A, Borghs, H, Slowikowska-Hilczer, J, Walczak-Jedrzejowska, R, Huhtaniemi, I, Wu, F, Silman, A, O'Neill, T, Finn, J, Steer, P, Lee, D, Pye, S, Casanueva, F, Lage, M, Földesi, I, Fejes, I, Korrovitz, P & Jiang, M 2009, 'Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men', Journal of Neurology, Neurosurgery and Psychiatry, vol. 80, no. 7, pp. 722-729. https://doi.org/10.1136/jnnp.2008.165720
Lee, David M. ; Tajar, Abdelouahid ; Ulubaev, Aslan ; Pendleton, Neil ; O'Neill, Terence W. ; O'Connor, Daryl B. ; Bártfai, G. ; Boonen, Steven ; Bouillon, Roger ; Casanueva, Felipe F. ; Finn, Joseph D. ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S. ; Huhtaniemi, Ilpo T. ; Kula, Krzysztof ; Lean, Michael E J ; Punab, Margus ; Silman, Alan J. ; Vanderschueren, Dirk ; Wu, Frederick C W ; Petrone, Luisa ; Cilotti, Antonio ; Borghs, Herman ; Slowikowska-Hilczer, Jolanta ; Walczak-Jedrzejowska, Renata ; Huhtaniemi, Ilpo ; Wu, Frederick ; Silman, Alan ; O'Neill, Terence ; Finn, Joseph ; Steer, Philip ; Lee, David ; Pye, Stephen ; Casanueva, Felipe ; Lage, Mary ; Földesi, I. ; Fejes, I. ; Korrovitz, Paul ; Jiang, Min. / Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. In: Journal of Neurology, Neurosurgery and Psychiatry. 2009 ; Vol. 80, No. 7. pp. 722-729.
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abstract = "Background: Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men. Methods: This population-based cross-sectional study included 3,369 men aged 40-79 years from eight centres enrolled in the European Male Ageing Study. Cognitive function was assessed using the Rey-Osterrieth Complex Figure (ROCF) test, the Camden Topographical Recognition Memory (CTRM) test and the Digit Symbol Substitution Test (DSST). Serum 25(OH)D levels were measured by radioimmunoassay. Additional assessments included measurement of physical activity, functional performance and mood/depression. Associations between cognitive function and 25(OH)D levels were explored using locally weighted and linear regression models. Results: In total, 3,133 men (mean (±SD) age 60±11 years) were included in the analysis. The mean (±SD) 25(OH)D concentration was 63±31 nmol/l. In ageadjusted linear regressions, high levels of 25(OH)D were associated with high scores on the copy component of the ROCF test (β per 10 nmol/l=0.096; 95{\%} CI 0.049 to 0.144), the CTRM test (β per 10 nmol/l=0.075; 95{\%} CI 0.026 to 0.124) and the DSST (β per 10 nmol/l=0.318; 95{\%} CI 0.235 to 0.401). After adjusting for additional confounders, 25(OH)D levels were associated with only score on the DSST (β per 10 nmol/l=0.152; 95{\%} CI 0.051 to 0.253). Locally weighted and spline regressions suggested the relationship between 25(OH)D concentration and cognitive function was most pronounced at 25(OH)D concentrations below 35 nmol/l. Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.",
author = "Lee, {David M.} and Abdelouahid Tajar and Aslan Ulubaev and Neil Pendleton and O'Neill, {Terence W.} and O'Connor, {Daryl B.} and G. B{\'a}rtfai and Steven Boonen and Roger Bouillon and Casanueva, {Felipe F.} and Finn, {Joseph D.} and Gianni Forti and Aleksander Giwercman and Han, {Thang S.} and Huhtaniemi, {Ilpo T.} and Krzysztof Kula and Lean, {Michael E J} and Margus Punab and Silman, {Alan J.} and Dirk Vanderschueren and Wu, {Frederick C W} and Luisa Petrone and Antonio Cilotti and Herman Borghs and Jolanta Slowikowska-Hilczer and Renata Walczak-Jedrzejowska and Ilpo Huhtaniemi and Frederick Wu and Alan Silman and Terence O'Neill and Joseph Finn and Philip Steer and David Lee and Stephen Pye and Felipe Casanueva and Mary Lage and I. F{\"o}ldesi and I. Fejes and Paul Korrovitz and Min Jiang",
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TY - JOUR

T1 - Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men

AU - Lee, David M.

AU - Tajar, Abdelouahid

AU - Ulubaev, Aslan

AU - Pendleton, Neil

AU - O'Neill, Terence W.

AU - O'Connor, Daryl B.

AU - Bártfai, G.

AU - Boonen, Steven

AU - Bouillon, Roger

AU - Casanueva, Felipe F.

AU - Finn, Joseph D.

AU - Forti, Gianni

AU - Giwercman, Aleksander

AU - Han, Thang S.

AU - Huhtaniemi, Ilpo T.

AU - Kula, Krzysztof

AU - Lean, Michael E J

AU - Punab, Margus

AU - Silman, Alan J.

AU - Vanderschueren, Dirk

AU - Wu, Frederick C W

AU - Petrone, Luisa

AU - Cilotti, Antonio

AU - Borghs, Herman

AU - Slowikowska-Hilczer, Jolanta

AU - Walczak-Jedrzejowska, Renata

AU - Huhtaniemi, Ilpo

AU - Wu, Frederick

AU - Silman, Alan

AU - O'Neill, Terence

AU - Finn, Joseph

AU - Steer, Philip

AU - Lee, David

AU - Pye, Stephen

AU - Casanueva, Felipe

AU - Lage, Mary

AU - Földesi, I.

AU - Fejes, I.

AU - Korrovitz, Paul

AU - Jiang, Min

PY - 2009/7

Y1 - 2009/7

N2 - Background: Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men. Methods: This population-based cross-sectional study included 3,369 men aged 40-79 years from eight centres enrolled in the European Male Ageing Study. Cognitive function was assessed using the Rey-Osterrieth Complex Figure (ROCF) test, the Camden Topographical Recognition Memory (CTRM) test and the Digit Symbol Substitution Test (DSST). Serum 25(OH)D levels were measured by radioimmunoassay. Additional assessments included measurement of physical activity, functional performance and mood/depression. Associations between cognitive function and 25(OH)D levels were explored using locally weighted and linear regression models. Results: In total, 3,133 men (mean (±SD) age 60±11 years) were included in the analysis. The mean (±SD) 25(OH)D concentration was 63±31 nmol/l. In ageadjusted linear regressions, high levels of 25(OH)D were associated with high scores on the copy component of the ROCF test (β per 10 nmol/l=0.096; 95% CI 0.049 to 0.144), the CTRM test (β per 10 nmol/l=0.075; 95% CI 0.026 to 0.124) and the DSST (β per 10 nmol/l=0.318; 95% CI 0.235 to 0.401). After adjusting for additional confounders, 25(OH)D levels were associated with only score on the DSST (β per 10 nmol/l=0.152; 95% CI 0.051 to 0.253). Locally weighted and spline regressions suggested the relationship between 25(OH)D concentration and cognitive function was most pronounced at 25(OH)D concentrations below 35 nmol/l. Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.

AB - Background: Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men. Methods: This population-based cross-sectional study included 3,369 men aged 40-79 years from eight centres enrolled in the European Male Ageing Study. Cognitive function was assessed using the Rey-Osterrieth Complex Figure (ROCF) test, the Camden Topographical Recognition Memory (CTRM) test and the Digit Symbol Substitution Test (DSST). Serum 25(OH)D levels were measured by radioimmunoassay. Additional assessments included measurement of physical activity, functional performance and mood/depression. Associations between cognitive function and 25(OH)D levels were explored using locally weighted and linear regression models. Results: In total, 3,133 men (mean (±SD) age 60±11 years) were included in the analysis. The mean (±SD) 25(OH)D concentration was 63±31 nmol/l. In ageadjusted linear regressions, high levels of 25(OH)D were associated with high scores on the copy component of the ROCF test (β per 10 nmol/l=0.096; 95% CI 0.049 to 0.144), the CTRM test (β per 10 nmol/l=0.075; 95% CI 0.026 to 0.124) and the DSST (β per 10 nmol/l=0.318; 95% CI 0.235 to 0.401). After adjusting for additional confounders, 25(OH)D levels were associated with only score on the DSST (β per 10 nmol/l=0.152; 95% CI 0.051 to 0.253). Locally weighted and spline regressions suggested the relationship between 25(OH)D concentration and cognitive function was most pronounced at 25(OH)D concentrations below 35 nmol/l. Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.

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