Association analysis of 5-HTTLPR variants, 5-HT2A receptor gene 102T/C polymorphism and migraine

G. Juhász, Terezia Zsombok, Andras Laszik, X. Gonda, P. Sótónyi, G. Faludi, G. Bagdy

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. There is evidence to suggest that serotonin-related genes participate in the pathogenesis of migraine. Previous studies have shown that gender differences influence the serotonergic neurotransmission and, in addition, the migraine prevalence is higher in females than males. Therefore, we investigated the functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) and the 102T/C polymorphism of the 5-HT2A receptor gene in the Hungarian female population. These genes were analysed in 126 migraine sufferers (with or without aura) and 101 unrelated healthy controls using case control design. A borderline association (χ2 = 3.84, df = 1, p = 0.049; OR = 1.45, 95% CI = 1.00-2.12) between 5-HTTLPR short (S) allele and migraine was found. No significant difference between migraine sufferers and controls was observed for the 102T/C polymorphism of 5-HT 2A receptor gene. Furthermore, there was no significant interaction between5-HTTLPR and 102T/C polymorphisms in our study population. In conclusion, our results support that the genetic susceptibility of migraine may be associated with a locus at or near the 5-HT transporter gene.

Original languageEnglish
Pages (from-to)231-240
Number of pages10
JournalJournal of Neurogenetics
Volume17
Issue number2-3
Publication statusPublished - Apr 2003

Fingerprint

Receptor, Serotonin, 5-HT2A
Migraine Disorders
Genes
Serotonin
Migraine without Aura
Migraine with Aura
Serotonin Plasma Membrane Transport Proteins
Nucleic Acid Regulatory Sequences
Genetic Predisposition to Disease
Synaptic Transmission
Population
Alleles

Keywords

  • 5-HT receptor
  • Human genotypes
  • Migraine
  • Polymorphism
  • Serotonin transporter

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics
  • Neuroscience(all)

Cite this

Association analysis of 5-HTTLPR variants, 5-HT2A receptor gene 102T/C polymorphism and migraine. / Juhász, G.; Zsombok, Terezia; Laszik, Andras; Gonda, X.; Sótónyi, P.; Faludi, G.; Bagdy, G.

In: Journal of Neurogenetics, Vol. 17, No. 2-3, 04.2003, p. 231-240.

Research output: Contribution to journalArticle

@article{857afed9b58f45ef8db923de4cc51468,
title = "Association analysis of 5-HTTLPR variants, 5-HT2A receptor gene 102T/C polymorphism and migraine",
abstract = "It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. There is evidence to suggest that serotonin-related genes participate in the pathogenesis of migraine. Previous studies have shown that gender differences influence the serotonergic neurotransmission and, in addition, the migraine prevalence is higher in females than males. Therefore, we investigated the functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) and the 102T/C polymorphism of the 5-HT2A receptor gene in the Hungarian female population. These genes were analysed in 126 migraine sufferers (with or without aura) and 101 unrelated healthy controls using case control design. A borderline association (χ2 = 3.84, df = 1, p = 0.049; OR = 1.45, 95{\%} CI = 1.00-2.12) between 5-HTTLPR short (S) allele and migraine was found. No significant difference between migraine sufferers and controls was observed for the 102T/C polymorphism of 5-HT 2A receptor gene. Furthermore, there was no significant interaction between5-HTTLPR and 102T/C polymorphisms in our study population. In conclusion, our results support that the genetic susceptibility of migraine may be associated with a locus at or near the 5-HT transporter gene.",
keywords = "5-HT receptor, Human genotypes, Migraine, Polymorphism, Serotonin transporter",
author = "G. Juh{\'a}sz and Terezia Zsombok and Andras Laszik and X. Gonda and P. S{\'o}t{\'o}nyi and G. Faludi and G. Bagdy",
year = "2003",
month = "4",
language = "English",
volume = "17",
pages = "231--240",
journal = "Journal of Neurogenetics",
issn = "0167-7063",
publisher = "Informa Healthcare",
number = "2-3",

}

TY - JOUR

T1 - Association analysis of 5-HTTLPR variants, 5-HT2A receptor gene 102T/C polymorphism and migraine

AU - Juhász, G.

AU - Zsombok, Terezia

AU - Laszik, Andras

AU - Gonda, X.

AU - Sótónyi, P.

AU - Faludi, G.

AU - Bagdy, G.

PY - 2003/4

Y1 - 2003/4

N2 - It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. There is evidence to suggest that serotonin-related genes participate in the pathogenesis of migraine. Previous studies have shown that gender differences influence the serotonergic neurotransmission and, in addition, the migraine prevalence is higher in females than males. Therefore, we investigated the functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) and the 102T/C polymorphism of the 5-HT2A receptor gene in the Hungarian female population. These genes were analysed in 126 migraine sufferers (with or without aura) and 101 unrelated healthy controls using case control design. A borderline association (χ2 = 3.84, df = 1, p = 0.049; OR = 1.45, 95% CI = 1.00-2.12) between 5-HTTLPR short (S) allele and migraine was found. No significant difference between migraine sufferers and controls was observed for the 102T/C polymorphism of 5-HT 2A receptor gene. Furthermore, there was no significant interaction between5-HTTLPR and 102T/C polymorphisms in our study population. In conclusion, our results support that the genetic susceptibility of migraine may be associated with a locus at or near the 5-HT transporter gene.

AB - It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. There is evidence to suggest that serotonin-related genes participate in the pathogenesis of migraine. Previous studies have shown that gender differences influence the serotonergic neurotransmission and, in addition, the migraine prevalence is higher in females than males. Therefore, we investigated the functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) and the 102T/C polymorphism of the 5-HT2A receptor gene in the Hungarian female population. These genes were analysed in 126 migraine sufferers (with or without aura) and 101 unrelated healthy controls using case control design. A borderline association (χ2 = 3.84, df = 1, p = 0.049; OR = 1.45, 95% CI = 1.00-2.12) between 5-HTTLPR short (S) allele and migraine was found. No significant difference between migraine sufferers and controls was observed for the 102T/C polymorphism of 5-HT 2A receptor gene. Furthermore, there was no significant interaction between5-HTTLPR and 102T/C polymorphisms in our study population. In conclusion, our results support that the genetic susceptibility of migraine may be associated with a locus at or near the 5-HT transporter gene.

KW - 5-HT receptor

KW - Human genotypes

KW - Migraine

KW - Polymorphism

KW - Serotonin transporter

UR - http://www.scopus.com/inward/record.url?scp=0346727583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346727583&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 231

EP - 240

JO - Journal of Neurogenetics

JF - Journal of Neurogenetics

SN - 0167-7063

IS - 2-3

ER -