Assisted reproductive technology in Europe, 2012: Results generated from European registers by ESHRE

C. Calhaz-Jorge, C. De Geyter, M. S. Kupka, J. De Mouzon, K. Erb, E. Mocanu, T. Motrenko, G. Scaravelli, C. Wyns, V. Goossens, Orion Gliozheni, Heinz Strohmer, Elena Petrovskaya, Oleg Tishkevich, Christine Wyns, Kris Bogaerts, Irena Antonova, Hrvoje Vrcic, Dejan Ljiljak, Karel RezabekJitka Markova, Josephine Lemmen, Karin Erb, Deniss Sõritsa, Mika Gissler, Aila Tiitinen, Dominique Royere, Andreas Tandler-Schneider, Monika Uszkoriet, Dimitris Loutradis, Basil C. Tarlatzis, J. Urbancsek, G. Kosztolányi, Hilmar Bjorgvinsson, Edgar Mocanu, Giulia Scaravelli, Vyacheslav Lokshin, Valiyev Ravil, Zivile Gudleviciene, Giedre Belo Lopes, Veaceslav Moshin, Tatjana Motrenko Simic, Dragana Vukicevic, Liv Bente Romundstad, Rafael Kurzawa, Carlos Calhaz-Jorge, Ana Rita Laranjeira, Ioana Rugescu, Bogdan Doroftei, Vladislav Korsak, Nebosja Radunovic, Sci Nada Tabs, Tomaz Tomazevic, Irma Virant-Klun, Juana Hernandez Hernandez, Jose Antonio Castilla Alcalá, Christina Bergh, Maya Weder, Christian De Geyter, Jesper M J Smeenk, Mykola Gryshchenko, Richard Baranowski

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Study Question The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? Summary Answer Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before. What is Known Already Since 1997, ART data in Europe have been collected and re-ported in 15 manuscripts, published in Human Reproduction. Study Design, Size, Duration Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Data for cycles between 1 January and 31 December 2012 were collected from National Registers, when existing, or on a voluntary basis by personal information. Participants/Materials, Setting, Methods From 34 countries (+1 compared with 2011), 1111 clinics reported 640 144 treatment cycles including 139 978 of IVF, 312 600 of ICSI, 139 558 of frozen embryo replacement (FER), 33 605 of egg donation (ED), 421 of in vitro maturation, 8433 of preimplantation genetic diagnosis/preimplantation genetic screening and 5549 of frozen oocyte replacements (FOR). European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1126 IUI labs in 24 countries. A total of 175 028 IUI-H and 43 497 IUI-D cycles were included. Main Results and the Role of Chance In 18 countries where all clinics reported to their ART register, a total of 369 081 ART cycles were performed in a population of around 295 million inhabitants, corresponding to 1252 cycles per million inhabitants (range 325-2732 cycles per million inhabitants). For all IVF cycles, the clinical PRs per aspiration and per transfer were stable with 29.4 (29.1% in 2011) and 33.8% (33.2% in 2011), respectively. For ICSI, the corresponding rates also were stable with 27.8 (27.9% in 2011) and 32.3% (31.8% in 2011). In FER cycles, the PR per thawing/warming increased to 23.1% (21.3% in 2011). In ED cycles, the PR per fresh transfer increased to 48.4% (45.8% in 2011) and to 35.9% (33.6% in 2011) per thawed transfer, while it was 45.1% for transfers after FOR. The delivery rate after IUI remained stable, at 8.5% (8.3% in 2011) after IUI-H and 12.0% (12.2% in 2011) after IUI-D. In IVF and ICSI cycles, 1, 2, 3 and 4+ embryos were transferred in 30.2, 55.4, 13.3 and 1.1% of the cycles, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (added together) were 82.1, 17.3 and 0.6%, respectively, resulting in a total multiple delivery rate of 17.9% compared with 19.2% in 2011 and 20.6% in 2010. In FER cycles, the multiple delivery rate was 12.5% (12.2% twins and 0.3% triplets). Twin and triplet delivery rates associated with IUI cycles were 9.0%/0.4% and 7.2%/0.5%, following treatment with husband and donor semen, respectively. LIMITATIONS, REASONS FOR CAUTION The method of reporting varies among countries, and registers from a number of countries have been unable to provide some of the relevant data such as initiated cycles and deliveries. As long as data are incomplete and generated through different methods of collection, results should be interpreted with caution. Wider Implications of the Findings The 16th ESHRE report on ART shows a continuing expansion of the number of treatment cycles in Europe, with more than 640 000 cycles reported in 2012 with an increasing contribution to birthrate in many countries. However, the need to improve and standardize the national registries, and to establish validation methodologies remains manifest. STUDY FUNDING/COMPETING INTERESTS The study has no external funding; all costs are covered by ESHRE. There are no competing interests.

Original languageEnglish
Pages (from-to)1638-1652
Number of pages15
JournalHuman Reproduction
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Assisted Reproductive Techniques
Embryology
Insemination
Reproduction
Intracytoplasmic Sperm Injections
Pregnancy Rate
Embryonic Structures
Oocytes
Preimplantation Diagnosis
Spouses
Ovum
Tissue Donors
Manuscripts
Genetic Testing
Therapeutics
Semen
Registries
Research Design
Costs and Cost Analysis

Keywords

  • data collection
  • egg donation
  • Europe
  • frozen embryo replacement
  • ICSI
  • intrauterine insemination
  • IVF
  • registry

ASJC Scopus subject areas

  • Reproductive Medicine
  • Rehabilitation
  • Obstetrics and Gynaecology

Cite this

Calhaz-Jorge, C., De Geyter, C., Kupka, M. S., De Mouzon, J., Erb, K., Mocanu, E., ... Baranowski, R. (2016). Assisted reproductive technology in Europe, 2012: Results generated from European registers by ESHRE. Human Reproduction, 31(8), 1638-1652. https://doi.org/10.1093/humrep/dew151

Assisted reproductive technology in Europe, 2012 : Results generated from European registers by ESHRE. / Calhaz-Jorge, C.; De Geyter, C.; Kupka, M. S.; De Mouzon, J.; Erb, K.; Mocanu, E.; Motrenko, T.; Scaravelli, G.; Wyns, C.; Goossens, V.; Gliozheni, Orion; Strohmer, Heinz; Petrovskaya, Elena; Tishkevich, Oleg; Wyns, Christine; Bogaerts, Kris; Antonova, Irena; Vrcic, Hrvoje; Ljiljak, Dejan; Rezabek, Karel; Markova, Jitka; Lemmen, Josephine; Erb, Karin; Sõritsa, Deniss; Gissler, Mika; Tiitinen, Aila; Royere, Dominique; Tandler-Schneider, Andreas; Uszkoriet, Monika; Loutradis, Dimitris; Tarlatzis, Basil C.; Urbancsek, J.; Kosztolányi, G.; Bjorgvinsson, Hilmar; Mocanu, Edgar; Scaravelli, Giulia; Lokshin, Vyacheslav; Ravil, Valiyev; Gudleviciene, Zivile; Lopes, Giedre Belo; Moshin, Veaceslav; Simic, Tatjana Motrenko; Vukicevic, Dragana; Romundstad, Liv Bente; Kurzawa, Rafael; Calhaz-Jorge, Carlos; Laranjeira, Ana Rita; Rugescu, Ioana; Doroftei, Bogdan; Korsak, Vladislav; Radunovic, Nebosja; Tabs, Sci Nada; Tomazevic, Tomaz; Virant-Klun, Irma; Hernandez, Juana Hernandez; Antonio Castilla Alcalá, Jose; Bergh, Christina; Weder, Maya; De Geyter, Christian; Smeenk, Jesper M J; Gryshchenko, Mykola; Baranowski, Richard.

In: Human Reproduction, Vol. 31, No. 8, 01.08.2016, p. 1638-1652.

Research output: Contribution to journalArticle

Calhaz-Jorge, C, De Geyter, C, Kupka, MS, De Mouzon, J, Erb, K, Mocanu, E, Motrenko, T, Scaravelli, G, Wyns, C, Goossens, V, Gliozheni, O, Strohmer, H, Petrovskaya, E, Tishkevich, O, Wyns, C, Bogaerts, K, Antonova, I, Vrcic, H, Ljiljak, D, Rezabek, K, Markova, J, Lemmen, J, Erb, K, Sõritsa, D, Gissler, M, Tiitinen, A, Royere, D, Tandler-Schneider, A, Uszkoriet, M, Loutradis, D, Tarlatzis, BC, Urbancsek, J, Kosztolányi, G, Bjorgvinsson, H, Mocanu, E, Scaravelli, G, Lokshin, V, Ravil, V, Gudleviciene, Z, Lopes, GB, Moshin, V, Simic, TM, Vukicevic, D, Romundstad, LB, Kurzawa, R, Calhaz-Jorge, C, Laranjeira, AR, Rugescu, I, Doroftei, B, Korsak, V, Radunovic, N, Tabs, SN, Tomazevic, T, Virant-Klun, I, Hernandez, JH, Antonio Castilla Alcalá, J, Bergh, C, Weder, M, De Geyter, C, Smeenk, JMJ, Gryshchenko, M & Baranowski, R 2016, 'Assisted reproductive technology in Europe, 2012: Results generated from European registers by ESHRE', Human Reproduction, vol. 31, no. 8, pp. 1638-1652. https://doi.org/10.1093/humrep/dew151
Calhaz-Jorge C, De Geyter C, Kupka MS, De Mouzon J, Erb K, Mocanu E et al. Assisted reproductive technology in Europe, 2012: Results generated from European registers by ESHRE. Human Reproduction. 2016 Aug 1;31(8):1638-1652. https://doi.org/10.1093/humrep/dew151
Calhaz-Jorge, C. ; De Geyter, C. ; Kupka, M. S. ; De Mouzon, J. ; Erb, K. ; Mocanu, E. ; Motrenko, T. ; Scaravelli, G. ; Wyns, C. ; Goossens, V. ; Gliozheni, Orion ; Strohmer, Heinz ; Petrovskaya, Elena ; Tishkevich, Oleg ; Wyns, Christine ; Bogaerts, Kris ; Antonova, Irena ; Vrcic, Hrvoje ; Ljiljak, Dejan ; Rezabek, Karel ; Markova, Jitka ; Lemmen, Josephine ; Erb, Karin ; Sõritsa, Deniss ; Gissler, Mika ; Tiitinen, Aila ; Royere, Dominique ; Tandler-Schneider, Andreas ; Uszkoriet, Monika ; Loutradis, Dimitris ; Tarlatzis, Basil C. ; Urbancsek, J. ; Kosztolányi, G. ; Bjorgvinsson, Hilmar ; Mocanu, Edgar ; Scaravelli, Giulia ; Lokshin, Vyacheslav ; Ravil, Valiyev ; Gudleviciene, Zivile ; Lopes, Giedre Belo ; Moshin, Veaceslav ; Simic, Tatjana Motrenko ; Vukicevic, Dragana ; Romundstad, Liv Bente ; Kurzawa, Rafael ; Calhaz-Jorge, Carlos ; Laranjeira, Ana Rita ; Rugescu, Ioana ; Doroftei, Bogdan ; Korsak, Vladislav ; Radunovic, Nebosja ; Tabs, Sci Nada ; Tomazevic, Tomaz ; Virant-Klun, Irma ; Hernandez, Juana Hernandez ; Antonio Castilla Alcalá, Jose ; Bergh, Christina ; Weder, Maya ; De Geyter, Christian ; Smeenk, Jesper M J ; Gryshchenko, Mykola ; Baranowski, Richard. / Assisted reproductive technology in Europe, 2012 : Results generated from European registers by ESHRE. In: Human Reproduction. 2016 ; Vol. 31, No. 8. pp. 1638-1652.
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title = "Assisted reproductive technology in Europe, 2012: Results generated from European registers by ESHRE",
abstract = "Study Question The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? Summary Answer Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before. What is Known Already Since 1997, ART data in Europe have been collected and re-ported in 15 manuscripts, published in Human Reproduction. Study Design, Size, Duration Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Data for cycles between 1 January and 31 December 2012 were collected from National Registers, when existing, or on a voluntary basis by personal information. Participants/Materials, Setting, Methods From 34 countries (+1 compared with 2011), 1111 clinics reported 640 144 treatment cycles including 139 978 of IVF, 312 600 of ICSI, 139 558 of frozen embryo replacement (FER), 33 605 of egg donation (ED), 421 of in vitro maturation, 8433 of preimplantation genetic diagnosis/preimplantation genetic screening and 5549 of frozen oocyte replacements (FOR). European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1126 IUI labs in 24 countries. A total of 175 028 IUI-H and 43 497 IUI-D cycles were included. Main Results and the Role of Chance In 18 countries where all clinics reported to their ART register, a total of 369 081 ART cycles were performed in a population of around 295 million inhabitants, corresponding to 1252 cycles per million inhabitants (range 325-2732 cycles per million inhabitants). For all IVF cycles, the clinical PRs per aspiration and per transfer were stable with 29.4 (29.1{\%} in 2011) and 33.8{\%} (33.2{\%} in 2011), respectively. For ICSI, the corresponding rates also were stable with 27.8 (27.9{\%} in 2011) and 32.3{\%} (31.8{\%} in 2011). In FER cycles, the PR per thawing/warming increased to 23.1{\%} (21.3{\%} in 2011). In ED cycles, the PR per fresh transfer increased to 48.4{\%} (45.8{\%} in 2011) and to 35.9{\%} (33.6{\%} in 2011) per thawed transfer, while it was 45.1{\%} for transfers after FOR. The delivery rate after IUI remained stable, at 8.5{\%} (8.3{\%} in 2011) after IUI-H and 12.0{\%} (12.2{\%} in 2011) after IUI-D. In IVF and ICSI cycles, 1, 2, 3 and 4+ embryos were transferred in 30.2, 55.4, 13.3 and 1.1{\%} of the cycles, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (added together) were 82.1, 17.3 and 0.6{\%}, respectively, resulting in a total multiple delivery rate of 17.9{\%} compared with 19.2{\%} in 2011 and 20.6{\%} in 2010. In FER cycles, the multiple delivery rate was 12.5{\%} (12.2{\%} twins and 0.3{\%} triplets). Twin and triplet delivery rates associated with IUI cycles were 9.0{\%}/0.4{\%} and 7.2{\%}/0.5{\%}, following treatment with husband and donor semen, respectively. LIMITATIONS, REASONS FOR CAUTION The method of reporting varies among countries, and registers from a number of countries have been unable to provide some of the relevant data such as initiated cycles and deliveries. As long as data are incomplete and generated through different methods of collection, results should be interpreted with caution. Wider Implications of the Findings The 16th ESHRE report on ART shows a continuing expansion of the number of treatment cycles in Europe, with more than 640 000 cycles reported in 2012 with an increasing contribution to birthrate in many countries. However, the need to improve and standardize the national registries, and to establish validation methodologies remains manifest. STUDY FUNDING/COMPETING INTERESTS The study has no external funding; all costs are covered by ESHRE. There are no competing interests.",
keywords = "data collection, egg donation, Europe, frozen embryo replacement, ICSI, intrauterine insemination, IVF, registry",
author = "C. Calhaz-Jorge and {De Geyter}, C. and Kupka, {M. S.} and {De Mouzon}, J. and K. Erb and E. Mocanu and T. Motrenko and G. Scaravelli and C. Wyns and V. Goossens and Orion Gliozheni and Heinz Strohmer and Elena Petrovskaya and Oleg Tishkevich and Christine Wyns and Kris Bogaerts and Irena Antonova and Hrvoje Vrcic and Dejan Ljiljak and Karel Rezabek and Jitka Markova and Josephine Lemmen and Karin Erb and Deniss S{\~o}ritsa and Mika Gissler and Aila Tiitinen and Dominique Royere and Andreas Tandler-Schneider and Monika Uszkoriet and Dimitris Loutradis and Tarlatzis, {Basil C.} and J. Urbancsek and G. Kosztol{\'a}nyi and Hilmar Bjorgvinsson and Edgar Mocanu and Giulia Scaravelli and Vyacheslav Lokshin and Valiyev Ravil and Zivile Gudleviciene and Lopes, {Giedre Belo} and Veaceslav Moshin and Simic, {Tatjana Motrenko} and Dragana Vukicevic and Romundstad, {Liv Bente} and Rafael Kurzawa and Carlos Calhaz-Jorge and Laranjeira, {Ana Rita} and Ioana Rugescu and Bogdan Doroftei and Vladislav Korsak and Nebosja Radunovic and Tabs, {Sci Nada} and Tomaz Tomazevic and Irma Virant-Klun and Hernandez, {Juana Hernandez} and {Antonio Castilla Alcal{\'a}}, Jose and Christina Bergh and Maya Weder and {De Geyter}, Christian and Smeenk, {Jesper M J} and Mykola Gryshchenko and Richard Baranowski",
year = "2016",
month = "8",
day = "1",
doi = "10.1093/humrep/dew151",
language = "English",
volume = "31",
pages = "1638--1652",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Assisted reproductive technology in Europe, 2012

T2 - Results generated from European registers by ESHRE

AU - Calhaz-Jorge, C.

AU - De Geyter, C.

AU - Kupka, M. S.

AU - De Mouzon, J.

AU - Erb, K.

AU - Mocanu, E.

AU - Motrenko, T.

AU - Scaravelli, G.

AU - Wyns, C.

AU - Goossens, V.

AU - Gliozheni, Orion

AU - Strohmer, Heinz

AU - Petrovskaya, Elena

AU - Tishkevich, Oleg

AU - Wyns, Christine

AU - Bogaerts, Kris

AU - Antonova, Irena

AU - Vrcic, Hrvoje

AU - Ljiljak, Dejan

AU - Rezabek, Karel

AU - Markova, Jitka

AU - Lemmen, Josephine

AU - Erb, Karin

AU - Sõritsa, Deniss

AU - Gissler, Mika

AU - Tiitinen, Aila

AU - Royere, Dominique

AU - Tandler-Schneider, Andreas

AU - Uszkoriet, Monika

AU - Loutradis, Dimitris

AU - Tarlatzis, Basil C.

AU - Urbancsek, J.

AU - Kosztolányi, G.

AU - Bjorgvinsson, Hilmar

AU - Mocanu, Edgar

AU - Scaravelli, Giulia

AU - Lokshin, Vyacheslav

AU - Ravil, Valiyev

AU - Gudleviciene, Zivile

AU - Lopes, Giedre Belo

AU - Moshin, Veaceslav

AU - Simic, Tatjana Motrenko

AU - Vukicevic, Dragana

AU - Romundstad, Liv Bente

AU - Kurzawa, Rafael

AU - Calhaz-Jorge, Carlos

AU - Laranjeira, Ana Rita

AU - Rugescu, Ioana

AU - Doroftei, Bogdan

AU - Korsak, Vladislav

AU - Radunovic, Nebosja

AU - Tabs, Sci Nada

AU - Tomazevic, Tomaz

AU - Virant-Klun, Irma

AU - Hernandez, Juana Hernandez

AU - Antonio Castilla Alcalá, Jose

AU - Bergh, Christina

AU - Weder, Maya

AU - De Geyter, Christian

AU - Smeenk, Jesper M J

AU - Gryshchenko, Mykola

AU - Baranowski, Richard

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Study Question The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? Summary Answer Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before. What is Known Already Since 1997, ART data in Europe have been collected and re-ported in 15 manuscripts, published in Human Reproduction. Study Design, Size, Duration Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Data for cycles between 1 January and 31 December 2012 were collected from National Registers, when existing, or on a voluntary basis by personal information. Participants/Materials, Setting, Methods From 34 countries (+1 compared with 2011), 1111 clinics reported 640 144 treatment cycles including 139 978 of IVF, 312 600 of ICSI, 139 558 of frozen embryo replacement (FER), 33 605 of egg donation (ED), 421 of in vitro maturation, 8433 of preimplantation genetic diagnosis/preimplantation genetic screening and 5549 of frozen oocyte replacements (FOR). European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1126 IUI labs in 24 countries. A total of 175 028 IUI-H and 43 497 IUI-D cycles were included. Main Results and the Role of Chance In 18 countries where all clinics reported to their ART register, a total of 369 081 ART cycles were performed in a population of around 295 million inhabitants, corresponding to 1252 cycles per million inhabitants (range 325-2732 cycles per million inhabitants). For all IVF cycles, the clinical PRs per aspiration and per transfer were stable with 29.4 (29.1% in 2011) and 33.8% (33.2% in 2011), respectively. For ICSI, the corresponding rates also were stable with 27.8 (27.9% in 2011) and 32.3% (31.8% in 2011). In FER cycles, the PR per thawing/warming increased to 23.1% (21.3% in 2011). In ED cycles, the PR per fresh transfer increased to 48.4% (45.8% in 2011) and to 35.9% (33.6% in 2011) per thawed transfer, while it was 45.1% for transfers after FOR. The delivery rate after IUI remained stable, at 8.5% (8.3% in 2011) after IUI-H and 12.0% (12.2% in 2011) after IUI-D. In IVF and ICSI cycles, 1, 2, 3 and 4+ embryos were transferred in 30.2, 55.4, 13.3 and 1.1% of the cycles, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (added together) were 82.1, 17.3 and 0.6%, respectively, resulting in a total multiple delivery rate of 17.9% compared with 19.2% in 2011 and 20.6% in 2010. In FER cycles, the multiple delivery rate was 12.5% (12.2% twins and 0.3% triplets). Twin and triplet delivery rates associated with IUI cycles were 9.0%/0.4% and 7.2%/0.5%, following treatment with husband and donor semen, respectively. LIMITATIONS, REASONS FOR CAUTION The method of reporting varies among countries, and registers from a number of countries have been unable to provide some of the relevant data such as initiated cycles and deliveries. As long as data are incomplete and generated through different methods of collection, results should be interpreted with caution. Wider Implications of the Findings The 16th ESHRE report on ART shows a continuing expansion of the number of treatment cycles in Europe, with more than 640 000 cycles reported in 2012 with an increasing contribution to birthrate in many countries. However, the need to improve and standardize the national registries, and to establish validation methodologies remains manifest. STUDY FUNDING/COMPETING INTERESTS The study has no external funding; all costs are covered by ESHRE. There are no competing interests.

AB - Study Question The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? Summary Answer Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before. What is Known Already Since 1997, ART data in Europe have been collected and re-ported in 15 manuscripts, published in Human Reproduction. Study Design, Size, Duration Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Data for cycles between 1 January and 31 December 2012 were collected from National Registers, when existing, or on a voluntary basis by personal information. Participants/Materials, Setting, Methods From 34 countries (+1 compared with 2011), 1111 clinics reported 640 144 treatment cycles including 139 978 of IVF, 312 600 of ICSI, 139 558 of frozen embryo replacement (FER), 33 605 of egg donation (ED), 421 of in vitro maturation, 8433 of preimplantation genetic diagnosis/preimplantation genetic screening and 5549 of frozen oocyte replacements (FOR). European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1126 IUI labs in 24 countries. A total of 175 028 IUI-H and 43 497 IUI-D cycles were included. Main Results and the Role of Chance In 18 countries where all clinics reported to their ART register, a total of 369 081 ART cycles were performed in a population of around 295 million inhabitants, corresponding to 1252 cycles per million inhabitants (range 325-2732 cycles per million inhabitants). For all IVF cycles, the clinical PRs per aspiration and per transfer were stable with 29.4 (29.1% in 2011) and 33.8% (33.2% in 2011), respectively. For ICSI, the corresponding rates also were stable with 27.8 (27.9% in 2011) and 32.3% (31.8% in 2011). In FER cycles, the PR per thawing/warming increased to 23.1% (21.3% in 2011). In ED cycles, the PR per fresh transfer increased to 48.4% (45.8% in 2011) and to 35.9% (33.6% in 2011) per thawed transfer, while it was 45.1% for transfers after FOR. The delivery rate after IUI remained stable, at 8.5% (8.3% in 2011) after IUI-H and 12.0% (12.2% in 2011) after IUI-D. In IVF and ICSI cycles, 1, 2, 3 and 4+ embryos were transferred in 30.2, 55.4, 13.3 and 1.1% of the cycles, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (added together) were 82.1, 17.3 and 0.6%, respectively, resulting in a total multiple delivery rate of 17.9% compared with 19.2% in 2011 and 20.6% in 2010. In FER cycles, the multiple delivery rate was 12.5% (12.2% twins and 0.3% triplets). Twin and triplet delivery rates associated with IUI cycles were 9.0%/0.4% and 7.2%/0.5%, following treatment with husband and donor semen, respectively. LIMITATIONS, REASONS FOR CAUTION The method of reporting varies among countries, and registers from a number of countries have been unable to provide some of the relevant data such as initiated cycles and deliveries. As long as data are incomplete and generated through different methods of collection, results should be interpreted with caution. Wider Implications of the Findings The 16th ESHRE report on ART shows a continuing expansion of the number of treatment cycles in Europe, with more than 640 000 cycles reported in 2012 with an increasing contribution to birthrate in many countries. However, the need to improve and standardize the national registries, and to establish validation methodologies remains manifest. STUDY FUNDING/COMPETING INTERESTS The study has no external funding; all costs are covered by ESHRE. There are no competing interests.

KW - data collection

KW - egg donation

KW - Europe

KW - frozen embryo replacement

KW - ICSI

KW - intrauterine insemination

KW - IVF

KW - registry

UR - http://www.scopus.com/inward/record.url?scp=84981276188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981276188&partnerID=8YFLogxK

U2 - 10.1093/humrep/dew151

DO - 10.1093/humrep/dew151

M3 - Article

C2 - 27496943

AN - SCOPUS:84981276188

VL - 31

SP - 1638

EP - 1652

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 8

ER -