Assisted fertilization by subzonal insemination and intracytoplasmic sperm injection.

A. Van Steirteghem, J. Liu, H. Joris, P. Nagy, C. Staessen, M. Camus, A. Wisanto, E. Van Assche, P. Devroey

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The results of 600 consecutive treatment cycles of subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) are described in couples with failed fertilization after standard IVF or insufficient spermatozoa in the ejaculate for IVF. More oocytes were damaged by ICSI (16.3%) than by SUZI (8.5%) and the normal fertilization rate was substantially higher after ICSI (49.1% v. 16.6%). Subsequent development of two-pronuclear oocytes in vitro was 80% after SUZI and 73.9% after ICSI. Significantly more triple embryo replacements were carried out after ICSI than after SUZI. Embryo transfers were possible in 421 of the 600 cycles. There were 63 pregnancies after ICSI (215 transfers) and 23 after SUZI (156 transfers); 10 additional pregnancies were achieved after 50 transfers of a mixture of SUZI and ICSI embryos. The results of fetal karyotypes and follow-up of the children do not indicate an increase in congenital malformations.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalReproduction, Fertility and Development
Volume6
Issue number1
Publication statusPublished - 1994

Fingerprint

intracytoplasmic sperm injection
Intracytoplasmic Sperm Injections
Insemination
fertilization (reproduction)
Fertilization
insemination
Oocytes
embryo (animal)
oocytes
Embryonic Structures
pregnancy
congenital abnormalities
Pregnancy
Embryo Transfer
embryo transfer
Karyotype
karyotyping
Spermatozoa
spermatozoa

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Developmental Biology
  • Endocrinology
  • Reproductive Medicine

Cite this

Van Steirteghem, A., Liu, J., Joris, H., Nagy, P., Staessen, C., Camus, M., ... Devroey, P. (1994). Assisted fertilization by subzonal insemination and intracytoplasmic sperm injection. Reproduction, Fertility and Development, 6(1), 85-89.

Assisted fertilization by subzonal insemination and intracytoplasmic sperm injection. / Van Steirteghem, A.; Liu, J.; Joris, H.; Nagy, P.; Staessen, C.; Camus, M.; Wisanto, A.; Van Assche, E.; Devroey, P.

In: Reproduction, Fertility and Development, Vol. 6, No. 1, 1994, p. 85-89.

Research output: Contribution to journalArticle

Van Steirteghem, A, Liu, J, Joris, H, Nagy, P, Staessen, C, Camus, M, Wisanto, A, Van Assche, E & Devroey, P 1994, 'Assisted fertilization by subzonal insemination and intracytoplasmic sperm injection.', Reproduction, Fertility and Development, vol. 6, no. 1, pp. 85-89.
Van Steirteghem, A. ; Liu, J. ; Joris, H. ; Nagy, P. ; Staessen, C. ; Camus, M. ; Wisanto, A. ; Van Assche, E. ; Devroey, P. / Assisted fertilization by subzonal insemination and intracytoplasmic sperm injection. In: Reproduction, Fertility and Development. 1994 ; Vol. 6, No. 1. pp. 85-89.
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