Assessment of respiratory mechanics with forced oscillations in healthy newborns

Z. Hantos, Dorottya Czövek, Zita Gyurkovits, Hajnalka Szabõ, Balázs A. Maár, Bence Radics, Katalin Virág, Gergely Makan, H. Orvos, Z. Gingl, Peter D. Sly

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Summary Background Lung function data in healthy newborn infants are scarce largely due to lack of suitable techniques, although data for developmental and prenatal exposure studies are much needed. We have modified the forced oscillation technique (FOT) for the measurement of respiratory mechanical impedance (Zrs) in unsedated sleeping infants in the first 3 days of life. Methods Zrs was measured during 30-s epochs of quiet sleep in term neonates born via spontaneous vaginal delivery with a non-invasive FOT between 8 and 48 Hz. Total respiratory resistance (R), compliance (C) and inertance (I) were obtained by fitting Zrs spectra. Cluster analysis was used to determine a set of minimal Zrs spectra representing optimal respiratory mechanics for each infant. Results Successful measurements were obtained in each of the first 3 days in 30/38 (78.9%) neonates. Group mean (± SD) values of R, C, I, and resonant frequency pooled for the 3 days were 45.9 ± 16.6 hPa s L-1, 0.97 ± 0.21 ml hPa-1, 0.082 ± 0.031 hPa s2 L-1 and 19.2 ± 3.2 Hz, respectively. Within-session variability represented by coefficient of variation was 5.34 ± 3.18% for R and 13.80 ± 8.57% for C. Greater between-session variability was observed for the individual infants; however, the only statistically significant change over time was a 13% increase in R from day 1 to day 2. Parameter interdependence was significant (r2 = 0.63) between R and I reflecting the large contribution of the upper airways to the total Zrs. Conclusions Noninvasive measurement of Zrs can be made in neonates during natural sleep with a high success rate, even in the first hours of life.

Original languageEnglish
Pages (from-to)344-352
Number of pages9
JournalPediatric Pulmonology
Volume50
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Respiratory Mechanics
Newborn Infant
Sleep
Electric Impedance
Compliance
Cluster Analysis
Lung

Keywords

  • infant pulmonary function
  • neonatal pulmonary medicine
  • pulmonary function testing (PFT)
  • pulmonary physiology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Hantos, Z., Czövek, D., Gyurkovits, Z., Szabõ, H., Maár, B. A., Radics, B., ... Sly, P. D. (2015). Assessment of respiratory mechanics with forced oscillations in healthy newborns. Pediatric Pulmonology, 50(4), 344-352. https://doi.org/10.1002/ppul.23103

Assessment of respiratory mechanics with forced oscillations in healthy newborns. / Hantos, Z.; Czövek, Dorottya; Gyurkovits, Zita; Szabõ, Hajnalka; Maár, Balázs A.; Radics, Bence; Virág, Katalin; Makan, Gergely; Orvos, H.; Gingl, Z.; Sly, Peter D.

In: Pediatric Pulmonology, Vol. 50, No. 4, 01.04.2015, p. 344-352.

Research output: Contribution to journalArticle

Hantos, Z, Czövek, D, Gyurkovits, Z, Szabõ, H, Maár, BA, Radics, B, Virág, K, Makan, G, Orvos, H, Gingl, Z & Sly, PD 2015, 'Assessment of respiratory mechanics with forced oscillations in healthy newborns', Pediatric Pulmonology, vol. 50, no. 4, pp. 344-352. https://doi.org/10.1002/ppul.23103
Hantos, Z. ; Czövek, Dorottya ; Gyurkovits, Zita ; Szabõ, Hajnalka ; Maár, Balázs A. ; Radics, Bence ; Virág, Katalin ; Makan, Gergely ; Orvos, H. ; Gingl, Z. ; Sly, Peter D. / Assessment of respiratory mechanics with forced oscillations in healthy newborns. In: Pediatric Pulmonology. 2015 ; Vol. 50, No. 4. pp. 344-352.
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abstract = "Summary Background Lung function data in healthy newborn infants are scarce largely due to lack of suitable techniques, although data for developmental and prenatal exposure studies are much needed. We have modified the forced oscillation technique (FOT) for the measurement of respiratory mechanical impedance (Zrs) in unsedated sleeping infants in the first 3 days of life. Methods Zrs was measured during 30-s epochs of quiet sleep in term neonates born via spontaneous vaginal delivery with a non-invasive FOT between 8 and 48 Hz. Total respiratory resistance (R), compliance (C) and inertance (I) were obtained by fitting Zrs spectra. Cluster analysis was used to determine a set of minimal Zrs spectra representing optimal respiratory mechanics for each infant. Results Successful measurements were obtained in each of the first 3 days in 30/38 (78.9{\%}) neonates. Group mean (± SD) values of R, C, I, and resonant frequency pooled for the 3 days were 45.9 ± 16.6 hPa s L-1, 0.97 ± 0.21 ml hPa-1, 0.082 ± 0.031 hPa s2 L-1 and 19.2 ± 3.2 Hz, respectively. Within-session variability represented by coefficient of variation was 5.34 ± 3.18{\%} for R and 13.80 ± 8.57{\%} for C. Greater between-session variability was observed for the individual infants; however, the only statistically significant change over time was a 13{\%} increase in R from day 1 to day 2. Parameter interdependence was significant (r2 = 0.63) between R and I reflecting the large contribution of the upper airways to the total Zrs. Conclusions Noninvasive measurement of Zrs can be made in neonates during natural sleep with a high success rate, even in the first hours of life.",
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AU - Czövek, Dorottya

AU - Gyurkovits, Zita

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AU - Maár, Balázs A.

AU - Radics, Bence

AU - Virág, Katalin

AU - Makan, Gergely

AU - Orvos, H.

AU - Gingl, Z.

AU - Sly, Peter D.

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N2 - Summary Background Lung function data in healthy newborn infants are scarce largely due to lack of suitable techniques, although data for developmental and prenatal exposure studies are much needed. We have modified the forced oscillation technique (FOT) for the measurement of respiratory mechanical impedance (Zrs) in unsedated sleeping infants in the first 3 days of life. Methods Zrs was measured during 30-s epochs of quiet sleep in term neonates born via spontaneous vaginal delivery with a non-invasive FOT between 8 and 48 Hz. Total respiratory resistance (R), compliance (C) and inertance (I) were obtained by fitting Zrs spectra. Cluster analysis was used to determine a set of minimal Zrs spectra representing optimal respiratory mechanics for each infant. Results Successful measurements were obtained in each of the first 3 days in 30/38 (78.9%) neonates. Group mean (± SD) values of R, C, I, and resonant frequency pooled for the 3 days were 45.9 ± 16.6 hPa s L-1, 0.97 ± 0.21 ml hPa-1, 0.082 ± 0.031 hPa s2 L-1 and 19.2 ± 3.2 Hz, respectively. Within-session variability represented by coefficient of variation was 5.34 ± 3.18% for R and 13.80 ± 8.57% for C. Greater between-session variability was observed for the individual infants; however, the only statistically significant change over time was a 13% increase in R from day 1 to day 2. Parameter interdependence was significant (r2 = 0.63) between R and I reflecting the large contribution of the upper airways to the total Zrs. Conclusions Noninvasive measurement of Zrs can be made in neonates during natural sleep with a high success rate, even in the first hours of life.

AB - Summary Background Lung function data in healthy newborn infants are scarce largely due to lack of suitable techniques, although data for developmental and prenatal exposure studies are much needed. We have modified the forced oscillation technique (FOT) for the measurement of respiratory mechanical impedance (Zrs) in unsedated sleeping infants in the first 3 days of life. Methods Zrs was measured during 30-s epochs of quiet sleep in term neonates born via spontaneous vaginal delivery with a non-invasive FOT between 8 and 48 Hz. Total respiratory resistance (R), compliance (C) and inertance (I) were obtained by fitting Zrs spectra. Cluster analysis was used to determine a set of minimal Zrs spectra representing optimal respiratory mechanics for each infant. Results Successful measurements were obtained in each of the first 3 days in 30/38 (78.9%) neonates. Group mean (± SD) values of R, C, I, and resonant frequency pooled for the 3 days were 45.9 ± 16.6 hPa s L-1, 0.97 ± 0.21 ml hPa-1, 0.082 ± 0.031 hPa s2 L-1 and 19.2 ± 3.2 Hz, respectively. Within-session variability represented by coefficient of variation was 5.34 ± 3.18% for R and 13.80 ± 8.57% for C. Greater between-session variability was observed for the individual infants; however, the only statistically significant change over time was a 13% increase in R from day 1 to day 2. Parameter interdependence was significant (r2 = 0.63) between R and I reflecting the large contribution of the upper airways to the total Zrs. Conclusions Noninvasive measurement of Zrs can be made in neonates during natural sleep with a high success rate, even in the first hours of life.

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