Assessment of recent process analytical technology (PAT) trends

A multiauthor review

Levente L. Simon, Hajnalka Pataki, G. Marosi, Fabian Meemken, Konrad Hungerbühler, Alfons Baiker, Srinivas Tummala, Brian Glennon, Martin Kuentz, Gerry Steele, Herman J M Kramer, James W. Rydzak, Zengping Chen, Julian Morris, Francois Kjell, Ravendra Singh, Rafiqul Gani, Krist V. Gernaey, Marjatta Louhi-Kultanen, John Oreilly & 26 others Niklas Sandler, Osmo Antikainen, Jouko Yliruusi, Patrick Frohberg, Joachim Ulrich, Richard D. Braatz, Tom Leyssens, Moritz Von Stosch, Rui Oliveira, Reginald B H Tan, Huiquan Wu, Mansoor Khan, Des Ogrady, Anjan Pandey, Remko Westra, Emmanuel Delle-Case, Detlef Pape, Daniele Angelosante, Yannick Maret, Olivier Steiger, Miklós Lenner, Kaoutar Abbou-Oucherif, Zoltan K. Nagy, James D. Litster, Vamsi Krishna Kamaraju, Min Sen Chiu

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

This multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture e.g. at GSK, AstraZeneca and Roche. Furthermore, the paper discusses the PAT paradigm from the regulatory science perspective. Given the multidisciplinary nature of PAT, such an endeavour would be almost impossible for a single author, so the concept of a multiauthor review was born. Each section of the multiauthor review has been written by a single expert or group of experts with the aim to report on its own research results. This paper also serves as a comprehensive source of information on PAT topics for the novice reader.

Original languageEnglish
Pages (from-to)3-62
Number of pages60
JournalOrganic Process Research and Development
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 16 2015

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trends
Industrial laboratories
sensors
Process monitoring
Process control
Sensors

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Assessment of recent process analytical technology (PAT) trends : A multiauthor review. / Simon, Levente L.; Pataki, Hajnalka; Marosi, G.; Meemken, Fabian; Hungerbühler, Konrad; Baiker, Alfons; Tummala, Srinivas; Glennon, Brian; Kuentz, Martin; Steele, Gerry; Kramer, Herman J M; Rydzak, James W.; Chen, Zengping; Morris, Julian; Kjell, Francois; Singh, Ravendra; Gani, Rafiqul; Gernaey, Krist V.; Louhi-Kultanen, Marjatta; Oreilly, John; Sandler, Niklas; Antikainen, Osmo; Yliruusi, Jouko; Frohberg, Patrick; Ulrich, Joachim; Braatz, Richard D.; Leyssens, Tom; Von Stosch, Moritz; Oliveira, Rui; Tan, Reginald B H; Wu, Huiquan; Khan, Mansoor; Ogrady, Des; Pandey, Anjan; Westra, Remko; Delle-Case, Emmanuel; Pape, Detlef; Angelosante, Daniele; Maret, Yannick; Steiger, Olivier; Lenner, Miklós; Abbou-Oucherif, Kaoutar; Nagy, Zoltan K.; Litster, James D.; Kamaraju, Vamsi Krishna; Chiu, Min Sen.

In: Organic Process Research and Development, Vol. 19, No. 1, 16.01.2015, p. 3-62.

Research output: Contribution to journalArticle

Simon, LL, Pataki, H, Marosi, G, Meemken, F, Hungerbühler, K, Baiker, A, Tummala, S, Glennon, B, Kuentz, M, Steele, G, Kramer, HJM, Rydzak, JW, Chen, Z, Morris, J, Kjell, F, Singh, R, Gani, R, Gernaey, KV, Louhi-Kultanen, M, Oreilly, J, Sandler, N, Antikainen, O, Yliruusi, J, Frohberg, P, Ulrich, J, Braatz, RD, Leyssens, T, Von Stosch, M, Oliveira, R, Tan, RBH, Wu, H, Khan, M, Ogrady, D, Pandey, A, Westra, R, Delle-Case, E, Pape, D, Angelosante, D, Maret, Y, Steiger, O, Lenner, M, Abbou-Oucherif, K, Nagy, ZK, Litster, JD, Kamaraju, VK & Chiu, MS 2015, 'Assessment of recent process analytical technology (PAT) trends: A multiauthor review', Organic Process Research and Development, vol. 19, no. 1, pp. 3-62. https://doi.org/10.1021/op500261y
Simon, Levente L. ; Pataki, Hajnalka ; Marosi, G. ; Meemken, Fabian ; Hungerbühler, Konrad ; Baiker, Alfons ; Tummala, Srinivas ; Glennon, Brian ; Kuentz, Martin ; Steele, Gerry ; Kramer, Herman J M ; Rydzak, James W. ; Chen, Zengping ; Morris, Julian ; Kjell, Francois ; Singh, Ravendra ; Gani, Rafiqul ; Gernaey, Krist V. ; Louhi-Kultanen, Marjatta ; Oreilly, John ; Sandler, Niklas ; Antikainen, Osmo ; Yliruusi, Jouko ; Frohberg, Patrick ; Ulrich, Joachim ; Braatz, Richard D. ; Leyssens, Tom ; Von Stosch, Moritz ; Oliveira, Rui ; Tan, Reginald B H ; Wu, Huiquan ; Khan, Mansoor ; Ogrady, Des ; Pandey, Anjan ; Westra, Remko ; Delle-Case, Emmanuel ; Pape, Detlef ; Angelosante, Daniele ; Maret, Yannick ; Steiger, Olivier ; Lenner, Miklós ; Abbou-Oucherif, Kaoutar ; Nagy, Zoltan K. ; Litster, James D. ; Kamaraju, Vamsi Krishna ; Chiu, Min Sen. / Assessment of recent process analytical technology (PAT) trends : A multiauthor review. In: Organic Process Research and Development. 2015 ; Vol. 19, No. 1. pp. 3-62.
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