Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies - Novel tool for diagnostics and patient follow-up

Liv T. Osnes, Britt Nakken, E. Bodolay, Peter Szodoray

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Serum and intracytoplasmic cytokines are mandatory in host defense against microbes, but also play a pivotal role in the pathogenesis of autoimmune diseases by initiating and perpetuating various cellular and humoral autoimmune processes.The intricate interplay and fine balance of pro- and anti-inflammatory processes drive, whether inflammation and eventually organ damage will occur, or the inflammatory cascade quenches. In the early and late, as well as inactive and active stages of autoimmune diseases, different cellular and molecular patterns can dominate in these patients. However, the simultaneous assessment of pro- and anti-inflammatory biomarkers aids to define the immunological state of a patient. A group of the most useful inflammatory biomarkers are cytokines, and with increasing knowledge during the last decade their role have been well-defined in patients with autoimmune diseases and immunodeficiencies. Multiple pathological processes drive the development of autoimmunity and immunodeficiencies, most of which involve quantitative and qualitative disturbances in regulatory cells, cytokine synthesis and signaling pathways. The assessment of these biomarkers does not aid only in the mechanistic description of autoimmune diseases and immunodeficiencies, but further helps to subcategorize diseases and to evaluate therapy responses.Here, we provide an overview, how monitoring of cytokines and regulatory cells aid in the diagnosis and follow-up of patients with autoimmune diseases and immunodeficiencies furthermore, we pinpoint novel cellular and molecular diagnostic possibilities in these diseases.

Original languageEnglish
Pages (from-to)967-971
Number of pages5
JournalAutoimmunity Reviews
Volume12
Issue number10
DOIs
Publication statusPublished - Aug 2013

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Autoimmune Diseases
Cytokines
Biomarkers
Anti-Inflammatory Agents
Molecular Pathology
Pathologic Processes
Autoimmunity
Inflammation
Serum
Therapeutics

Keywords

  • Autoimmune diseases
  • Immunodeficiencies
  • Immunoregulatory abnormalities
  • Regulatory T cells
  • Soluble, intracellular cytokines
  • Th17 cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies - Novel tool for diagnostics and patient follow-up. / Osnes, Liv T.; Nakken, Britt; Bodolay, E.; Szodoray, Peter.

In: Autoimmunity Reviews, Vol. 12, No. 10, 08.2013, p. 967-971.

Research output: Contribution to journalArticle

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