Assessment of edema using STIR+ via 3D cardiovascular magnetic resonance imaging in patients with suspected myocarditis

Michael Jeserich, B. Merkely, Pascal Schlosser, Simone Kimmel, Gabor Pavlik, Stephan Achenbach

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To evaluate three-dimensional T2-weighted fast spin echo triple inversion recovery sequences (STIR+) for the diagnosis of myocardial edema in patients with suspected early myocarditis after respiratory or gastrointestinal tract viral infection and at follow-up. Materials and methods: We prospectively examined 28 patients with suspected myocarditis and 37 controls matched for gender and age. An ECG-triggered STIR+ was used to cover the entire left ventricle in short-axis images with 10-mm slice thickness and no interslice gap. The global signal intensity ratio (heart muscle in relation to skeletal muscle) was calculated (global STIR+ ratio) to evaluate edema. All patients had repeat examinations at follow-up (mean interval 4.9 months, 1–12 months). Results: The mean global STIR+ ratio was 2.15 ± 0.4 in the initial examination of patients as compared to 1.78 ± 0.3 in controls (p < 0.0001) and 1.89 ± 0.3 in patients at follow-up (p = 0.0001 vs. first visit). Left ventricular ejection fraction did not differ between patients and controls at baseline and at follow-up. Conclusion: We could identify a significantly higher global STIR+ ratio in patients with suspected myocarditis compared to controls, and a dynamic change during follow-up. The global STIR+ ratio may, therefore, be useful for the diagnosis of myocarditis and should be further explored.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
DOIs
Publication statusAccepted/In press - Jan 16 2017

Keywords

  • Cardiovascular magnetic resonance imaging
  • Late gadolinium enhancement
  • Left ventricular function
  • Modified three-dimensional T2-weighted fast spin echo triple inversion recovery sequence
  • Myocarditis
  • STIR+

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

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