Assessing exposure misclassification by expert assessment in multicenter occupational studies

Andrea 'T Mannetje, Joelle Fevotte, Tony Fletcher, Paul Brennan, Joszef Legoza, Maria Szeremi, A. Páldy, Slawomir Brzeznicki, Jan Gromiec, Carmen Ruxanda-Artenie, Rodica Stanescu-Dumitru, Nicolai Ivanov, Raphael Shterengorz, Lubica Hettychova, Daniela Krizanova, Adrian Cassidy, Martie Van Tongeren, Paolo Boffetta

Research output: Contribution to journalArticle

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Abstract

Background: In a multicenter case-control study of lung cancer in central and eastern Europe and in Liverpool, exposure to occupational agents was assessed by teams of local experts. We performed an interteam agreement study to estimate the levels of exposure misclassification and the expected attenuation of the risk estimate. Methods: Eight teams of experts and a reference rater assessed exposure to 70 putative lung carcinogens for 19 jobs. Agreement among teams was calculated through Cohen's kappa, sensitivity, and specificity. Results: Each team showed an overall fair to good agreement with the reference (kappa between 0.53 and 0.64). The agreement among teams in the presence of exposure was excellent for 9 agents, fair to good for 16, and poor for 29. For all agents the specificity was high (average 0.94), although sensitivity varied considerably. Conclusions: This study of expert exposure assessment showed a small range in reliability among teams of experts, but large differences among agents. This paper presents the range in levels of misclassification that can be expected using experts for assessing occupational exposure to different agents, and the attenuation of the odds ratio that can be expected to result from this misclassification.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalEpidemiology
Volume14
Issue number5
DOIs
Publication statusPublished - Sep 2003

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Occupational Exposure
Multicenter Studies
Eastern Europe
Carcinogens
Case-Control Studies
Lung Neoplasms
Odds Ratio
Sensitivity and Specificity
Lung

Keywords

  • Agreement
  • Attenuation
  • Expert
  • Misclassification
  • Multicenter case-control studies
  • Occupational exposure

ASJC Scopus subject areas

  • Epidemiology

Cite this

'T Mannetje, A., Fevotte, J., Fletcher, T., Brennan, P., Legoza, J., Szeremi, M., ... Boffetta, P. (2003). Assessing exposure misclassification by expert assessment in multicenter occupational studies. Epidemiology, 14(5), 585-592. https://doi.org/10.1097/01.ede.0000072108.66723.0f

Assessing exposure misclassification by expert assessment in multicenter occupational studies. / 'T Mannetje, Andrea; Fevotte, Joelle; Fletcher, Tony; Brennan, Paul; Legoza, Joszef; Szeremi, Maria; Páldy, A.; Brzeznicki, Slawomir; Gromiec, Jan; Ruxanda-Artenie, Carmen; Stanescu-Dumitru, Rodica; Ivanov, Nicolai; Shterengorz, Raphael; Hettychova, Lubica; Krizanova, Daniela; Cassidy, Adrian; Van Tongeren, Martie; Boffetta, Paolo.

In: Epidemiology, Vol. 14, No. 5, 09.2003, p. 585-592.

Research output: Contribution to journalArticle

'T Mannetje, A, Fevotte, J, Fletcher, T, Brennan, P, Legoza, J, Szeremi, M, Páldy, A, Brzeznicki, S, Gromiec, J, Ruxanda-Artenie, C, Stanescu-Dumitru, R, Ivanov, N, Shterengorz, R, Hettychova, L, Krizanova, D, Cassidy, A, Van Tongeren, M & Boffetta, P 2003, 'Assessing exposure misclassification by expert assessment in multicenter occupational studies', Epidemiology, vol. 14, no. 5, pp. 585-592. https://doi.org/10.1097/01.ede.0000072108.66723.0f
'T Mannetje A, Fevotte J, Fletcher T, Brennan P, Legoza J, Szeremi M et al. Assessing exposure misclassification by expert assessment in multicenter occupational studies. Epidemiology. 2003 Sep;14(5):585-592. https://doi.org/10.1097/01.ede.0000072108.66723.0f
'T Mannetje, Andrea ; Fevotte, Joelle ; Fletcher, Tony ; Brennan, Paul ; Legoza, Joszef ; Szeremi, Maria ; Páldy, A. ; Brzeznicki, Slawomir ; Gromiec, Jan ; Ruxanda-Artenie, Carmen ; Stanescu-Dumitru, Rodica ; Ivanov, Nicolai ; Shterengorz, Raphael ; Hettychova, Lubica ; Krizanova, Daniela ; Cassidy, Adrian ; Van Tongeren, Martie ; Boffetta, Paolo. / Assessing exposure misclassification by expert assessment in multicenter occupational studies. In: Epidemiology. 2003 ; Vol. 14, No. 5. pp. 585-592.
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