Aspirin use and risk of stroke in the elderly: The Rotterdam Study

Zoltán Vokó, Peter J. Koudstaal, Michiel L. Bots, Albert Hofman, Monique M.B. Breteler

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The objective of the study was to assess the association between aspirin use and the risk of stroke in a population-based study in the elderly. The study was carried out within the framework of the Rotterdam Study, a prospective population-based cohort study. In the total study population there was a weak, nonsignificant association between aspirin use and the risk of stroke (adjusted relative risk 1.29, 95% CI 0.91-1.83). Stratification by history of vascular diseases revealed that aspirin considerably increased the risk of first-ever stroke in subjects free from vascular disease (adjusted relative risk 1.80; 95% CI 1.03-3.13). In persons with vascular disease, no association was observed between aspirin use and risk of stroke (adjusted relative risk 0.99, 95% CI 0.56-1.73). Our findings suggest that aspirin use may increase the risk of stroke in elderly subjects free from vascular disease.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalNeuroepidemiology
Volume20
Issue number1
DOIs
Publication statusPublished - Mar 6 2001

    Fingerprint

Keywords

  • Aspirin
  • Cerebrovascular disorders
  • Cohort studies
  • Primary prevention

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Vokó, Z., Koudstaal, P. J., Bots, M. L., Hofman, A., & Breteler, M. M. B. (2001). Aspirin use and risk of stroke in the elderly: The Rotterdam Study. Neuroepidemiology, 20(1), 40-44. https://doi.org/10.1159/000054756