Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs

S. J. Coker, I. Ledingham McA., J. Parratt, I. J. Zeitlin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Acute coronary artery occlusion in anaesthetized openchest greyhounds led to early release of thromboxane B2 (TxB2) into venous blood draining the ischaemic region. No release occurred from the remainder of the left ventricular wall (coronary sinus sampling). TxB2 release and ventricular ectopic activity were positively correlated (r=0.863) 2 min post-occlusion. Aspirin (3 mg/kg i.v.) suppressed both local TxB2 release and ectopic activity and prevented ventricular fibrillation. It is suggested that TxB2 release is a factor contributing to early post-infarction arrhythmias.

Original languageEnglish
Pages (from-to)593-595
Number of pages3
JournalBritish Journal of Pharmacology
Volume72
Issue number4
Publication statusPublished - 1981

Fingerprint

Thromboxane B2
Coronary Occlusion
Aspirin
Coronary Vessels
Dogs
Coronary Sinus
Ventricular Fibrillation
Infarction
Cardiac Arrhythmias

ASJC Scopus subject areas

  • Pharmacology

Cite this

Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. / Coker, S. J.; Ledingham McA., I.; Parratt, J.; Zeitlin, I. J.

In: British Journal of Pharmacology, Vol. 72, No. 4, 1981, p. 593-595.

Research output: Contribution to journalArticle

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