Aspirin and clopidogrel resistance: Possible mechanisms and clinical relevance. Part II: Potential causes and laboratory tests

Dávid Vadász, László K. Sztriha, Katalin Sas, László Vécsei

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Recent meta-analyses have indicated that patients with vascular disease demonstrated by laboratory tests to be aspirin or clopidogrel-resistant are at an increased risk of major vascular events. The suggested mechanisms of aspirin resistance include genetic polymorphism, alternative pathways of platelet activation, aspirin-insensitive thromboxane biosynthesis, drug interactions, or a low aspirin dose. Clopidogrel resistance is likely to develop as a result of a decreased bioavailability of the active metabolite, due to genetic variation or concomitant drug treatment. Additional work is required to improve and validate laboratory tests of platelet function, so that they may become useful tools for selection of the most appropriate antiplatelet therapy for an individual patient. Improvements in antiplatelet treatment strategies in the future should lead to a reduction in premature vascular events.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalIdeggyogyaszati szemle
Volume66
Issue number1-2
Publication statusPublished - Jan 30 2013

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Keywords

  • Antiplatelets
  • Aspirin resistance
  • Clopidogrel resistance
  • Pharmacotherapy
  • Prevention

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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