Aspirin and clopidogrel resistance: Possible mechanisms and clinical relevance. Part I: Concept of resistance

Dávid Vadász, László K. Sztriha, K. Sas, L. Vécsei

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aspirin and clopidogrel are well established as antiplatelet medication in the treatment of atherothrombotic vascular disease. However, despite treatment, a substantial number of patients experience recurrent ischemic episodes, referred to as aspirin or clopidogrel treatment failure. Various laboratory techniques are available with which to evaluate the effectiveness of antiplatelet drugs. Interestingly, the agreement between the results of the different tests may be poor. The term aspirin or clopidogrel resistance denotes those conditions in which an inadequate inhibitory efficacy of the given antiplatelet agent is detected by an in vitro assay of platelet function. It has been estimated that on average some 30% of patients treated with aspirin, and 20% on clopidogrel, do not achieve an appropriate level of efficacy as concerns platelet activity.

Original languageEnglish
Pages (from-to)377-385
Number of pages9
JournalIdeggyógyászati szemle
Volume65
Issue number11-12
Publication statusPublished - Nov 30 2012

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clopidogrel
Aspirin
Platelet Aggregation Inhibitors
Blood Platelets
Treatment Failure
Vascular Diseases
Therapeutics

Keywords

  • Aspririn
  • Clopidogrel
  • Vascular diseases

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Aspirin and clopidogrel resistance : Possible mechanisms and clinical relevance. Part I: Concept of resistance. / Vadász, Dávid; Sztriha, László K.; Sas, K.; Vécsei, L.

In: Ideggyógyászati szemle, Vol. 65, No. 11-12, 30.11.2012, p. 377-385.

Research output: Contribution to journalArticle

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