Asphyxia-induced release of α-melanocyte-stimulating hormone in newborn pigs

József Kovács, János Julesz, Mónika V. Mogyoróssy, Mária A. Deli, Csongor S. Ábrahám, Miklós Vecsernyés

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Asphyxia and reperfusion induced changes in the plasma and cerebrospinal fluid (CSF) concentrations of α-melanocyte-stimulating hormone (α-MSH) were studied in newborn pigs using a specific radioimmunoassay technique. Cardiovascular and metabolic failure induced by neonatal asphyxia resulted in a 3-fold, significant (P < 0.05) increase in plasma α-MSH levels, whereas the hormone concentration in CSF was significantly (P < 0.05) reduced by 50% during postasphyxial reperfusion. Our data indicate an asphyxia-induced release of α-MSH, and suggest a discordant regulation of plasma and CSF concentrations in newborn pigs.

Original languageEnglish
Pages (from-to)1049-1053
Number of pages5
JournalPeptides
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 17 2001

Keywords

  • Asphyxia
  • Cerebrospinal fluid
  • Newborn
  • Plasma
  • Resuscitation
  • α-melanocyte-stimulating hormone

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Asphyxia-induced release of α-melanocyte-stimulating hormone in newborn pigs'. Together they form a unique fingerprint.

  • Cite this