Asphyxia and reperfusion induced changes in the plasma and cerebrospinal fluid (CSF) concentrations of α-melanocyte-stimulating hormone (α-MSH) were studied in newborn pigs using a specific radioimmunoassay technique. Cardiovascular and metabolic failure induced by neonatal asphyxia resulted in a 3-fold, significant (P < 0.05) increase in plasma α-MSH levels, whereas the hormone concentration in CSF was significantly (P < 0.05) reduced by 50% during postasphyxial reperfusion. Our data indicate an asphyxia-induced release of α-MSH, and suggest a discordant regulation of plasma and CSF concentrations in newborn pigs.
- Cerebrospinal fluid
- α-melanocyte-stimulating hormone
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience