Asphyxia-induced release of α-melanocyte-stimulating hormone in newborn pigs

József Kovács, J. Julesz, Mónika V. Mogyoróssy, M. Deli, C. Ábrahám, M. Vecsernyés

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Asphyxia and reperfusion induced changes in the plasma and cerebrospinal fluid (CSF) concentrations of α-melanocyte-stimulating hormone (α-MSH) were studied in newborn pigs using a specific radioimmunoassay technique. Cardiovascular and metabolic failure induced by neonatal asphyxia resulted in a 3-fold, significant (P <0.05) increase in plasma α-MSH levels, whereas the hormone concentration in CSF was significantly (P <0.05) reduced by 50% during postasphyxial reperfusion. Our data indicate an asphyxia-induced release of α-MSH, and suggest a discordant regulation of plasma and CSF concentrations in newborn pigs.

Original languageEnglish
Pages (from-to)1049-1053
Number of pages5
JournalPeptides
Volume22
Issue number7
DOIs
Publication statusPublished - 2001

Fingerprint

Cerebrospinal fluid
Melanocyte-Stimulating Hormones
Asphyxia
Cerebrospinal Fluid
Swine
Plasmas
Reperfusion
Radioimmunoassay
Hormones

Keywords

  • α-melanocyte-stimulating hormone
  • Asphyxia
  • Cerebrospinal fluid
  • Newborn
  • Plasma
  • Resuscitation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Asphyxia-induced release of α-melanocyte-stimulating hormone in newborn pigs. / Kovács, József; Julesz, J.; Mogyoróssy, Mónika V.; Deli, M.; Ábrahám, C.; Vecsernyés, M.

In: Peptides, Vol. 22, No. 7, 2001, p. 1049-1053.

Research output: Contribution to journalArticle

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