Aspergillus niger citric acid accumulation: Do we understand this well working black box?

L. Karaffa, Christian P. Kubicek

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

This Mini-Review summarizes the current knowledge on the biochemical and physiological events leading to massive citric acid accumulation by Aspergillus niger under industrially comparable conditions, thereby particularly emphasizing the roles of glycolytic flux and its control, excretion of citric acid from the mitochondria and the cytosol, and the critical fermentation variables. The potential of novel techniques for metabolic analysis and genomic approaches in understanding this fermentation is also discussed.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalApplied Microbiology and Biotechnology
Volume61
Issue number3
Publication statusPublished - May 2003

Fingerprint

Aspergillus niger
Aspergillus
Citric acid
Citric Acid
Fermentation
Mitochondria
Cytosol
Fluxes

ASJC Scopus subject areas

  • Biotechnology
  • Microbiology
  • Bioengineering

Cite this

Aspergillus niger citric acid accumulation : Do we understand this well working black box? / Karaffa, L.; Kubicek, Christian P.

In: Applied Microbiology and Biotechnology, Vol. 61, No. 3, 05.2003, p. 189-196.

Research output: Contribution to journalArticle

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