Aseptic necrosis at multiple localisations in a lupus patient with lymphoma

A. Bazso, T. Bazso, P. Szodoray, G. Poór, E. Kiss

Research output: Contribution to journalArticle

Abstract

Avascular or aseptic necrosis is a well-defined entity leading to the degradation of cellular elements of the bone. The pathogenesis of osteonecrosis (ON) is still unknown. There are two main types of ON: traumatic or non-traumatic. Several clinical entities could associate with ON, systemic diseases, environmental factors, pregnancy, systemic autoimmune or rheumatic diseases, thrombophilia, corticosteroid therapy, cytotoxic dugs, infections, metabolic and hematologic diseases, etc. Corticosteroids (CS) are still the most frequently used therapeutic options in the early phase and during flares of these diseases. Inflammatory cytokines and antibodies have been described to participate in the pathogenesis of ON. The infiltrative disorders of the bone marrow could also contribute to the development of ON. Hereby, we describe a female patient with NHL followed by SLE in whom ON has developed at least in two localisations. Lupus flare, long-term CS therapy, lymphoma relapse or the presence of antiphospholipid antibodies were excluded. Although the bi-localised ON could be contributed to immunologic factors or trauma, the exact aetiology in this case could not be elucidated.

Original languageEnglish
Pages (from-to)1415-1417
Number of pages3
JournalOsteoporosis International
Volume25
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Osteonecrosis
Lymphoma
Necrosis
Adrenal Cortex Hormones
Antiphospholipid Antibodies
Thrombophilia
Hematologic Diseases
Metabolic Diseases
Immunologic Factors
Rheumatic Diseases
Autoimmune Diseases
Therapeutics
Bone Marrow
Cytokines
Bone and Bones
Recurrence
Pregnancy
Antibodies
Wounds and Injuries
Infection

Keywords

  • Antiphospholipid antibodies
  • Aseptic necrosis
  • Corticosteroid
  • NHL
  • SLE

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Aseptic necrosis at multiple localisations in a lupus patient with lymphoma. / Bazso, A.; Bazso, T.; Szodoray, P.; Poór, G.; Kiss, E.

In: Osteoporosis International, Vol. 25, No. 4, 2014, p. 1415-1417.

Research output: Contribution to journalArticle

Bazso, A. ; Bazso, T. ; Szodoray, P. ; Poór, G. ; Kiss, E. / Aseptic necrosis at multiple localisations in a lupus patient with lymphoma. In: Osteoporosis International. 2014 ; Vol. 25, No. 4. pp. 1415-1417.
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