Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles

Miklós Csala, Valéria Mile, Angelo Benedetti, József Mandl, Gábor Bánhegyi

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26 Citations (Scopus)

Abstract

Oxidation and uptake of ascorbate show similar time courses in rat liver microsomal vesicles: a rapid burst phase is followed by a slower process. Inhibitors of ascorbate oxidation (proadifen, econazole or quercetin) also effectively decreased the uptake of ascorbate. The results show that dehydroascorbate is the transport form of ascorbate at the membrane of the endoplasmic reticulum.

Original languageEnglish
Pages (from-to)413-415
Number of pages3
JournalBiochemical Journal
Volume349
Issue number2
DOIs
Publication statusPublished - Jul 15 2000

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Keywords

  • Dehydroascorbate
  • Endoplasmic recticulum
  • Protein disulphide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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