Artiodactyl IgD: The missing link

Yaofeng Zhao, I. Kacskovics, Qiang Pan, David A. Liberles, Janos Geli, Scott K. Davis, Hodjattallah Rabbani, Lennart Hammarstrom

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

IgD has been suggested to be a recently developed Ig class, only present in rodents and primates. However, in this paper the cow, sheep, and pig Ig ⊃ genes have been identified and shown to be transcriptionally active. The deduced amino acid sequences from their cDNAs show that artiodactyl IgD H chains are structurally similar to human IgD, where the cow, sheep, and pig IgD H chain constant regions all contain three domains and a hinge region, sharing homologies of 43.6, 44, and 46.8% with their human counterpart, respectively. According to a phylogenetic analysis, the Cδ gene appears to have been duplicated from the Cμ gene ≥300 million yr ago. The ruminant μCH1 exon and its upstream region was again duplicated before the speciation of the cow and sheep, ∼20 million yr ago, inserted upstream of the δ gene hinge regions, and later modified by gene conversion. A short Sδ (switch δ) sequence resulting from the second duplication, is located immediately upstream of the bovine Cδ gene and directs regular μ-δ class switch recombination in the cow. The presence of Cδ genes in artiodactyls, possibly in most mammals, suggests that IgD may have some as yet unknown biological properties, distinct from those of IgM, conferring a survival advantage.

Original languageEnglish
Pages (from-to)4408-4416
Number of pages9
JournalJournal of Immunology
Volume169
Issue number8
Publication statusPublished - Oct 15 2002

Fingerprint

Immunoglobulin D
Sheep
Genes
Swine
Gene Conversion
Immunoglobulin Genes
Ruminants
Primates
Genetic Recombination
Immunoglobulin M
Mammals
Amino Acid Sequence
Exons
Rodentia
Complementary DNA
Survival

ASJC Scopus subject areas

  • Immunology

Cite this

Zhao, Y., Kacskovics, I., Pan, Q., Liberles, D. A., Geli, J., Davis, S. K., ... Hammarstrom, L. (2002). Artiodactyl IgD: The missing link. Journal of Immunology, 169(8), 4408-4416.

Artiodactyl IgD : The missing link. / Zhao, Yaofeng; Kacskovics, I.; Pan, Qiang; Liberles, David A.; Geli, Janos; Davis, Scott K.; Rabbani, Hodjattallah; Hammarstrom, Lennart.

In: Journal of Immunology, Vol. 169, No. 8, 15.10.2002, p. 4408-4416.

Research output: Contribution to journalArticle

Zhao, Y, Kacskovics, I, Pan, Q, Liberles, DA, Geli, J, Davis, SK, Rabbani, H & Hammarstrom, L 2002, 'Artiodactyl IgD: The missing link', Journal of Immunology, vol. 169, no. 8, pp. 4408-4416.
Zhao Y, Kacskovics I, Pan Q, Liberles DA, Geli J, Davis SK et al. Artiodactyl IgD: The missing link. Journal of Immunology. 2002 Oct 15;169(8):4408-4416.
Zhao, Yaofeng ; Kacskovics, I. ; Pan, Qiang ; Liberles, David A. ; Geli, Janos ; Davis, Scott K. ; Rabbani, Hodjattallah ; Hammarstrom, Lennart. / Artiodactyl IgD : The missing link. In: Journal of Immunology. 2002 ; Vol. 169, No. 8. pp. 4408-4416.
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