Artichoke (Cynara scolymus L.) extracts are showing concentration-dependent hormetic and cytotoxic effects on breast cancer cell lines

Szabolcs Vígh, Zsanett Zsvér-Vadas, Ciprian Pribac, Liana Moş, Zoltán Cziáky, Mária Czapár, Ciprian Valentin Mihali, Violeta Turcuş, E. Máthé

Research output: Contribution to journalArticle

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Abstract

Chemomapping of artichoke (Cynara scolymus L.) leaf extracts revealed novel bioactive compounds with putative anti-tumor effects, and therefore, we set to analyze the cytotoxic effects of aqueous and alcoholic extracts on T-47D and ZR-75-1 human breast cancer cell lines. A concentration dependent hormetic response was detected in the case of aqueous extract, while the alcoholic extract featured a pronounced cytotoxic effect as inferred by the MTT proliferation assays. Immunocytochemical analyses of treated cells were suggesting that the observed cytotoxicity could be associated with cellular senescence and/or apoptosis. Our experimental data are suggesting that the artichoke could be a good candidate for the complementary treatment of certain human cancers but further studies are needed to shed light on all aspects related to its hormetic dose response and cytotoxic effect not talking about the putative hepatoprotective effect in relation to cancer therapy efficiency.

Original languageEnglish
Pages (from-to)423-433
Number of pages11
JournalStudia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii
Volume26
Issue number4
Publication statusPublished - 2016

Fingerprint

Cynara cardunculus subsp. cardunculus
Cynara scolymus
artichokes
breast neoplasms
cytotoxicity
cancer
Cells
cell lines
Breast Neoplasms
Cell Line
extracts
alcohol abuse
Cytotoxicity
Hormesis
neoplasms
Tumors
Assays
Neoplasms
Cell Aging
Apoptosis

Keywords

  • Artichoke
  • Cynara scolymus L
  • Cytotoxicity
  • Hormesis
  • Human breast cancer

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Artichoke (Cynara scolymus L.) extracts are showing concentration-dependent hormetic and cytotoxic effects on breast cancer cell lines. / Vígh, Szabolcs; Zsvér-Vadas, Zsanett; Pribac, Ciprian; Moş, Liana; Cziáky, Zoltán; Czapár, Mária; Mihali, Ciprian Valentin; Turcuş, Violeta; Máthé, E.

In: Studia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii, Vol. 26, No. 4, 2016, p. 423-433.

Research output: Contribution to journalArticle

Vígh, Szabolcs ; Zsvér-Vadas, Zsanett ; Pribac, Ciprian ; Moş, Liana ; Cziáky, Zoltán ; Czapár, Mária ; Mihali, Ciprian Valentin ; Turcuş, Violeta ; Máthé, E. / Artichoke (Cynara scolymus L.) extracts are showing concentration-dependent hormetic and cytotoxic effects on breast cancer cell lines. In: Studia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii. 2016 ; Vol. 26, No. 4. pp. 423-433.
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